Cyclodextrin-based targeting strategies for tumor treatment

Juan Juan Yin, Zhi Wei Zhou, Shu Feng Zhou

Research output: Contribution to journalReview articlepeer-review

Abstract

The efficacy and applicability of anticancer drugs are greatly restricted by severe systemic toxicities and drug resistance. Targeting drug delivery strategies have been developed to prevent the shortcomings of chemotherapy. Among various approaches to specifically target drug-loaded carrier systems to the required pathological sites, ligand-attached cyclodextrin-based targeting complexes are a promising drug delivery system, which is achieved mainly through specific molecular interactions between the drugs and cell surface receptors. The principal targeting tactics include conjugation of cyclodextrin with targeting moieties or encapsulation drugs in cyclodextrins. The cyclodextrin-based supramolecules, polymers, or nanoparticles bearing bioactive substances such as folate, estrogens, carbohydrates, peptides, etc. have been reviewed.

Original languageEnglish (US)
Pages (from-to)364-374
Number of pages11
JournalDrug Delivery and Translational Research
Volume3
Issue number4
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Anticancer drug
  • Cyclodextrin
  • Inclusion
  • Ligand
  • Targeting

ASJC Scopus subject areas

  • Pharmaceutical Science

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