Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing

Perrie M. Adams, Jill D. Fabricant, Marvin S. Legator

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.

Original languageEnglish (US)
Pages (from-to)80-82
Number of pages3
JournalScience
Volume211
Issue number4477
DOIs
StatePublished - Jan 1 1981

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