Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing

Perrie M. Adams; Jill D. Fabricant; Marvin S. Legator

doi:10.1126/science.7444453

Cyclophosphamide-induced spermatogenic effects detected in the F ₁ generation by behavioral testing

Perrie M. Adams, Jill D. Fabricant, Marvin S. Legator

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Abstract

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F₁ progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.

Original language	English (US)
Pages (from-to)	80-82
Number of pages	3
Journal	Science
Volume	211
Issue number	4477
DOIs	https://doi.org/10.1126/science.7444453
State	Published - Jan 1 1981

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title = "Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing",

abstract = "Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.",

author = "Adams, {Perrie M.} and Fabricant, {Jill D.} and Legator, {Marvin S.}",

year = "1981",

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AU - Fabricant, Jill D.

AU - Legator, Marvin S.

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AB - Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.

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Cyclophosphamide-induced spermatogenic effects detected in the F ₁ generation by behavioral testing

Abstract

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