Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing

Perrie M. Adams, Jill D. Fabricant, Marvin S. Legator

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Abstract

Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.

Original languageEnglish (US)
Pages (from-to)80-82
Number of pages3
JournalScience
Volume211
Issue number4477
StatePublished - 1981

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Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing. / Adams, Perrie M.; Fabricant, Jill D.; Legator, Marvin S.

In: Science, Vol. 211, No. 4477, 1981, p. 80-82.

Research output: Contribution to journalArticle

Adams, Perrie M. ; Fabricant, Jill D. ; Legator, Marvin S. / Cyclophosphamide-induced spermatogenic effects detected in the F 1 generation by behavioral testing. In: Science. 1981 ; Vol. 211, No. 4477. pp. 80-82.
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