Abstract
Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.
Original language | English (US) |
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Pages (from-to) | 731-736 |
Number of pages | 6 |
Journal | FASEB Journal |
Volume | 6 |
Issue number | 2 |
State | Published - Jan 6 1992 |
Keywords
- Arachidonate
- Eicosanoids
- Epoxygenase
- Hydroxyeicosatetraenoic acids
- Omega oxidation
- P450
- Prostanoids
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Biochemistry
- Biotechnology