Cytochrome P450 and the arachidonate cascade

Jorge H. Capdevila, J R Falck, Ronald W. Estabrook

Research output: Contribution to journalArticle

260 Citations (Scopus)

Abstract

Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

Original languageEnglish (US)
Pages (from-to)731-736
Number of pages6
JournalFASEB Journal
Volume6
Issue number2
StatePublished - Jan 6 1992

Fingerprint

cytochrome P-450
Cytochrome P-450 Enzyme System
Hydroxylation
Peroxides
functional diversity
hydroxylation
Metabolites
peroxides
arachidonic acid
Arachidonic Acid
Metabolism
oxidation
metabolites
Oxidation
metabolism
Substrates
Research

Keywords

  • Arachidonate
  • Eicosanoids
  • Epoxygenase
  • Hydroxyeicosatetraenoic acids
  • Omega oxidation
  • P450
  • Prostanoids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Capdevila, J. H., Falck, J. R., & Estabrook, R. W. (1992). Cytochrome P450 and the arachidonate cascade. FASEB Journal, 6(2), 731-736.

Cytochrome P450 and the arachidonate cascade. / Capdevila, Jorge H.; Falck, J R; Estabrook, Ronald W.

In: FASEB Journal, Vol. 6, No. 2, 06.01.1992, p. 731-736.

Research output: Contribution to journalArticle

Capdevila, JH, Falck, JR & Estabrook, RW 1992, 'Cytochrome P450 and the arachidonate cascade', FASEB Journal, vol. 6, no. 2, pp. 731-736.
Capdevila JH, Falck JR, Estabrook RW. Cytochrome P450 and the arachidonate cascade. FASEB Journal. 1992 Jan 6;6(2):731-736.
Capdevila, Jorge H. ; Falck, J R ; Estabrook, Ronald W. / Cytochrome P450 and the arachidonate cascade. In: FASEB Journal. 1992 ; Vol. 6, No. 2. pp. 731-736.
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