Cytochrome P450 and the arachidonate cascade

Jorge H. Capdevila, J R Falck, Ronald W. Estabrook

Research output: Contribution to journalArticle

260 Scopus citations

Abstract

Arachidonic acid and many products of the arachidonate cascade serve as substrates for cytochrome P450-mediated metabolism via allylic oxidation, omega hydroxylation, and epoxygenation as well as peroxide rearrangement. Defining the physiological importance of these metabolites is an area of intense research interest. Cytochrome P450-catalyzed reactions play prominent roles in multiplying the structural and functional diversity of the arachidonate metabolic cascade.

Original languageEnglish (US)
Pages (from-to)731-736
Number of pages6
JournalFASEB Journal
Volume6
Issue number2
Publication statusPublished - Jan 6 1992

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Keywords

  • Arachidonate
  • Eicosanoids
  • Epoxygenase
  • Hydroxyeicosatetraenoic acids
  • Omega oxidation
  • P450
  • Prostanoids

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Capdevila, J. H., Falck, J. R., & Estabrook, R. W. (1992). Cytochrome P450 and the arachidonate cascade. FASEB Journal, 6(2), 731-736.