Cytodiagnosis of a primary effusion lymphoma: A case report

Manjunath S. Vadmal, Thorn F. Smilari, Judith P. Brody, Prasad Koduru, Steven I. Hajdu

Research output: Contribution to journalArticle

8 Scopus citations


BACKGROUND: Primary effusion lymphoma (PEL), commonly described in AIDS patients, is a unique subset of lymphoma in which the neoplastic lymphocytes proliferate exclusively in serous cavities. CASE: A 27-year-old male, HIV positive for five years and with multiple opportunistic infections in the past, was admitted for sudden-onset shortness of breath caused by a pleural effusion. Cytologic examination of the pleural fluid revealed medium to large atypical lymphocytes with a high mitosis rate, suspicious for lymphoma. Further diagnostic tests, such as immunophenotypic analysis and cytogenetic and molecular studies, confirmed the diagnosis of PEL. CONCLUSION: Cytopathologists and cytotechnologists should be aware of this new entity since additional studies are required for a definitive diagnosis.

Original languageEnglish (US)
Pages (from-to)374-376
Number of pages3
JournalActa Cytologica
Issue number2
StatePublished - Jan 1 1998



  • AIDS-associated lymphoma
  • Burkitt's translocation
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Vadmal, M. S., Smilari, T. F., Brody, J. P., Koduru, P., & Hajdu, S. I. (1998). Cytodiagnosis of a primary effusion lymphoma: A case report. Acta Cytologica, 42(2), 374-376.