Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

H. Nagasawa, J. B. Little, W. C. Inkret, S. Carpenter, K. Thompson, M. R. Raju, D. J. Chen, G. F. Strniste

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalMutation Research Letters
Volume244
Issue number3
DOIs
StatePublished - Jul 1990

Keywords

  • Alpha-particle irradation, low doses
  • CHO K-1 cells
  • Plutonium-238, extremely low doses, alpha-particle irradation

ASJC Scopus subject areas

  • Medicine(all)

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    Nagasawa, H., Little, J. B., Inkret, W. C., Carpenter, S., Thompson, K., Raju, M. R., Chen, D. J., & Strniste, G. F. (1990). Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. Mutation Research Letters, 244(3), 233-238. https://doi.org/10.1016/0165-7992(90)90134-6