Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells

H. Nagasawa, J. B. Little, W. C. Inkret, S. Carpenter, K. Thompson, M. R. Raju, D. J. Chen, G. F. Strniste

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

CHO K-1 cells were irradiated during the G1 phase with 0.5-6 rad of alpha particles. There was no appreciable cell killing in this low dose range. Significantly increased frequencies of sister-chromatid exchanges were induced by doses as low as 0.5 rad of alpha-particle irradiation, whereas increased numbers of chromosomal aberrations were observed following exposure to 2 rad. These results suggest that very low doses of alpha radiation may lead to radiation-induced genetic alterations.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalMutation Research Letters
Volume244
Issue number3
DOIs
StatePublished - 1990

Fingerprint

Alpha Particles
Plutonium
Alpha particles
Cytogenetics
Dosimetry
Irradiation
Radiation
Radiation Genetics
Aberrations
Sister Chromatid Exchange
Cells
G1 Phase
Chromosome Aberrations

Keywords

  • Alpha-particle irradation, low doses
  • CHO K-1 cells
  • Plutonium-238, extremely low doses, alpha-particle irradation

ASJC Scopus subject areas

  • Genetics
  • Toxicology
  • Medicine(all)

Cite this

Nagasawa, H., Little, J. B., Inkret, W. C., Carpenter, S., Thompson, K., Raju, M. R., ... Strniste, G. F. (1990). Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. Mutation Research Letters, 244(3), 233-238. https://doi.org/10.1016/0165-7992(90)90134-6

Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. / Nagasawa, H.; Little, J. B.; Inkret, W. C.; Carpenter, S.; Thompson, K.; Raju, M. R.; Chen, D. J.; Strniste, G. F.

In: Mutation Research Letters, Vol. 244, No. 3, 1990, p. 233-238.

Research output: Contribution to journalArticle

Nagasawa, H, Little, JB, Inkret, WC, Carpenter, S, Thompson, K, Raju, MR, Chen, DJ & Strniste, GF 1990, 'Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells', Mutation Research Letters, vol. 244, no. 3, pp. 233-238. https://doi.org/10.1016/0165-7992(90)90134-6
Nagasawa, H. ; Little, J. B. ; Inkret, W. C. ; Carpenter, S. ; Thompson, K. ; Raju, M. R. ; Chen, D. J. ; Strniste, G. F. / Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. In: Mutation Research Letters. 1990 ; Vol. 244, No. 3. pp. 233-238.
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