Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells

Akira Takashima, Paul R. Bergstresser

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Dendritic epidermal T cells (DETC) are skin-specific members of the epithelial γδ T-cell family that reside normally in murine epidermis. Recent studies indicate that certain cytokines (e.g. IL-2, IL-7 and IL-15) secreted by neighboring cells promote their residence and regulate their immune function. Conversely, DETC regulate the function of neighboring keratinocytes and Langerhans cells by elaborating other cytokines (e.g. interferon-γ, keratinocyte growth factor and colony-stimulating factors). This reciprocal interaction represents a unique model of cytokine-mediated intercellular communication by tissue-specific γδ T cells with nearby epithelial and antigen presenting cells.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalSeminars in Immunology
Volume8
Issue number6
DOIs
StatePublished - Dec 1996

Fingerprint

Langerhans Cells
Keratinocytes
Cytokines
T-Lymphocytes
Fibroblast Growth Factor 7
Colony-Stimulating Factors
Interleukin-15
Interleukin-7
Antigen-Presenting Cells
Epidermis
Interferons
Interleukin-2
Epithelial Cells
Skin

Keywords

  • Cytokines
  • DETC
  • Intercellular communication
  • Keratinocytes
  • Langerhans cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells. / Takashima, Akira; Bergstresser, Paul R.

In: Seminars in Immunology, Vol. 8, No. 6, 12.1996, p. 333-339.

Research output: Contribution to journalArticle

Takashima, Akira ; Bergstresser, Paul R. / Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells. In: Seminars in Immunology. 1996 ; Vol. 8, No. 6. pp. 333-339.
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