Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells

Akira Takashima, Paul R. Bergstresser

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Dendritic epidermal T cells (DETC) are skin-specific members of the epithelial γδ T-cell family that reside normally in murine epidermis. Recent studies indicate that certain cytokines (e.g. IL-2, IL-7 and IL-15) secreted by neighboring cells promote their residence and regulate their immune function. Conversely, DETC regulate the function of neighboring keratinocytes and Langerhans cells by elaborating other cytokines (e.g. interferon-γ, keratinocyte growth factor and colony-stimulating factors). This reciprocal interaction represents a unique model of cytokine-mediated intercellular communication by tissue-specific γδ T cells with nearby epithelial and antigen presenting cells.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalSeminars in Immunology
Volume8
Issue number6
DOIs
StatePublished - Dec 1996

Keywords

  • Cytokines
  • DETC
  • Intercellular communication
  • Keratinocytes
  • Langerhans cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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