TY - JOUR
T1 - Cytokine receptor endocytosis
T2 - New kinase activity-dependent and -independent roles of PI3K
AU - Chen, Ping Hung
AU - Yao, Huiyu
AU - Huang, Lily Jun Shen
N1 - Funding Information:
The authors are grateful to their colleagues Drs. Sandra Schmid and Peter Michaely, who generously shared their insights. They apologize to the many researchers whose work was not discussed because of space constraints. This study was supported by funding from the National Institutes of Health, USA to LJH (HL089966) and a Taiwan National Science Council Grant (103-2917-I-564-029) to PHC.
Publisher Copyright:
© 2017 Chen, Yao and Huang.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development. One key mechanism that regulates signaling from cytokine receptors is through receptor endocytosis. In this mini-review, we describe recent advances in endocytic regulations of cytokine receptors, focusing on new paradigms by which PI3K controls receptor endocytosis through both kinase activity-dependent and -independent mechanisms. These advances underscore the notion that the p85 regulatory subunit of PI3K has functions beyond regulating PI3K kinase activity, and that PI3K plays both positive and negative roles in receptor signaling. On the one hand, the PI3K/Akt pathway controls various aspects downstream of cytokine receptors. On the other hand, it stimulates receptor endocytosis and downregulation, thus contributing to signaling attenuation.
AB - Type I and II cytokine receptors are cell surface sensors that bind cytokines in the extracellular environment and initiate intracellular signaling to control processes such as hematopoiesis, immune function, and cellular growth and development. One key mechanism that regulates signaling from cytokine receptors is through receptor endocytosis. In this mini-review, we describe recent advances in endocytic regulations of cytokine receptors, focusing on new paradigms by which PI3K controls receptor endocytosis through both kinase activity-dependent and -independent mechanisms. These advances underscore the notion that the p85 regulatory subunit of PI3K has functions beyond regulating PI3K kinase activity, and that PI3K plays both positive and negative roles in receptor signaling. On the one hand, the PI3K/Akt pathway controls various aspects downstream of cytokine receptors. On the other hand, it stimulates receptor endocytosis and downregulation, thus contributing to signaling attenuation.
KW - Cytokine receptor
KW - Endocytic pathway
KW - Endocytosis
KW - PI3K
KW - Receptor downregulation
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U2 - 10.3389/fendo.2017.00078
DO - 10.3389/fendo.2017.00078
M3 - Article
C2 - 28507533
AN - SCOPUS:85019989548
SN - 1664-2392
VL - 8
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - MAY
M1 - 78
ER -