Cytokine regulation of fibroblast growth factor receptor 3 IIIb in intestinal epithelial cells

Michiyuki Kanai, Ian Rosenberg, Daniel K. Podolsky

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Proliferation and function of the intestinal epithelium is modulated by a range of regulatory peptides, including cytokines and peptide growth factors. To define mechanisms integrating these regulatory systems, the effects of growth factors and cytokines on the expression of the fibroblast growth factor (FGF) receptor 3 (FGFR3) IIIb expressed on intestinal epithelial cells were examined in Caco-2 cells. Regulated expression of FGFR3 IIIb was associated with acquisition of the differentiated state. Keratinocyte growth factor (KGF), a ligand of another member of the FGF receptor family, enhanced expression of FGFR3 IIIb, but acidic FGF, the ligand for FGFR3 IIIb itself, had no effect. Epidermal growth factor and transforming growth factor-β also markedly enhanced FGFR3 IIIb expression in a different temporal pattern. In addition, FGFR3 IIIb expression was increased 10-fold by the cytokine interleukin-2. These studies demonstrate integration between cytokines and growth factor ligand-receptor systems in intestinal epithelial cells.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume272
Issue number4 35-4
StatePublished - Apr 1997

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Receptor, Fibroblast Growth Factor, Type 3
Fibroblast Growth Factor Receptors
Epithelial Cells
Cytokines
Ligands
Intercellular Signaling Peptides and Proteins
Fibroblast Growth Factor 7
Fibroblast Growth Factor 1
Peptides
Caco-2 Cells
Growth Factor Receptors
Transforming Growth Factors
Intestinal Mucosa
Epidermal Growth Factor
Interleukin-2

Keywords

  • Caco-2
  • cytokine
  • intestinal cell
  • peptide growth factor

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology
  • Physiology (medical)

Cite this

Cytokine regulation of fibroblast growth factor receptor 3 IIIb in intestinal epithelial cells. / Kanai, Michiyuki; Rosenberg, Ian; Podolsky, Daniel K.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 272, No. 4 35-4, 04.1997.

Research output: Contribution to journalArticle

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