Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

M. D. Sadick, N. Street, T. R. Mosmann, R. M. Locksley

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

Original languageEnglish (US)
Pages (from-to)4710-4714
Number of pages5
JournalInfection and Immunity
Volume59
Issue number12
StatePublished - 1991

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Leishmaniasis
Inbred C57BL Mouse
Interleukin-4
Leishmania major
Cytokines
Nippostrongylus
Infection
Coinfection

ASJC Scopus subject areas

  • Immunology

Cite this

Cytokine regulation of murine leishmaniasis : Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice. / Sadick, M. D.; Street, N.; Mosmann, T. R.; Locksley, R. M.

In: Infection and Immunity, Vol. 59, No. 12, 1991, p. 4710-4714.

Research output: Contribution to journalArticle

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