Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

M. D. Sadick; N. Street; T. R. Mosmann; R. M. Locksley

Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

M. D. Sadick, N. Street, T. R. Mosmann, R. M. Locksley

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

Original language	English (US)
Pages (from-to)	4710-4714
Number of pages	5
Journal	Infection and immunity
Volume	59
Issue number	12
State	Published - 1991

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

Cite this

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title = "Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice",

abstract = "Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.",

author = "Sadick, {M. D.} and N. Street and Mosmann, {T. R.} and Locksley, {R. M.}",

year = "1991",

language = "English (US)",

volume = "59",

pages = "4710--4714",

journal = "Infection and immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

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T1 - Cytokine regulation of murine leishmaniasis

T2 - Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

AU - Sadick, M. D.

AU - Street, N.

AU - Mosmann, T. R.

AU - Locksley, R. M.

PY - 1991

Y1 - 1991

N2 - Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

AB - Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

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M3 - Comment/debate

C2 - 1937832

AN - SCOPUS:0025831105

SN - 0019-9567

VL - 59

SP - 4710

EP - 4714

JO - Infection and immunity

JF - Infection and immunity

IS - 12

ER -

Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

Abstract

ASJC Scopus subject areas

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