Cytokine regulation of murine leishmaniasis: Interleukin 4 is not sufficient to mediate progressive disease in resistant C57BL/6 mice

M. D. Sadick, N. Street, T. R. Mosmann, R. M. Locksley

Research output: Contribution to journalComment/debate

38 Scopus citations

Abstract

Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

Original languageEnglish (US)
Pages (from-to)4710-4714
Number of pages5
JournalInfection and immunity
Volume59
Issue number12
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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