Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut

Huaqi Jiang, Parthive H. Patel, Alexander Kohlmaier, Marc O. Grenley, Donald G. McEwen, Bruce A. Edgar

Research output: Contribution to journalArticle

522 Citations (Scopus)

Abstract

Cells in intestinal epithelia turn over rapidly due to damage from digestion and toxins produced by the enteric microbiota. Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to replenish the intestinal epithelium, but little is known about how ISC division and differentiation are coordinated with epithelial cell loss. We show here that when enterocytes (ECs) in the Drosophila midgut are subjected to apoptosis, enteric infection, or JNK-mediated stress signaling, they produce cytokines (Upd, Upd2, and Upd3) that activate Jak/Stat signaling in ISCs, promoting their rapid division. Upd/Jak/Stat activity also promotes progenitor cell differentiation, in part by stimulating Delta/Notch signaling, and is required for differentiation in both normal and regenerating midguts. Hence, cytokine-mediated feedback enables stem cells to replace spent progeny as they are lost, thereby establishing gut homeostasis.

Original languageEnglish (US)
Pages (from-to)1343-1355
Number of pages13
JournalCell
Volume137
Issue number7
DOIs
StatePublished - Jun 26 2009

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Stem cells
Drosophila
Regeneration
Homeostasis
Stem Cells
Cytokines
Intestinal Mucosa
Enterocytes
Microbiota
Apoptosis
Feedback
Cell Differentiation
Digestion
Epithelial Cells
Infection

Keywords

  • DEVBIO

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jiang, H., Patel, P. H., Kohlmaier, A., Grenley, M. O., McEwen, D. G., & Edgar, B. A. (2009). Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut. Cell, 137(7), 1343-1355. https://doi.org/10.1016/j.cell.2009.05.014

Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut. / Jiang, Huaqi; Patel, Parthive H.; Kohlmaier, Alexander; Grenley, Marc O.; McEwen, Donald G.; Edgar, Bruce A.

In: Cell, Vol. 137, No. 7, 26.06.2009, p. 1343-1355.

Research output: Contribution to journalArticle

Jiang, H, Patel, PH, Kohlmaier, A, Grenley, MO, McEwen, DG & Edgar, BA 2009, 'Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut', Cell, vol. 137, no. 7, pp. 1343-1355. https://doi.org/10.1016/j.cell.2009.05.014
Jiang H, Patel PH, Kohlmaier A, Grenley MO, McEwen DG, Edgar BA. Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut. Cell. 2009 Jun 26;137(7):1343-1355. https://doi.org/10.1016/j.cell.2009.05.014
Jiang, Huaqi ; Patel, Parthive H. ; Kohlmaier, Alexander ; Grenley, Marc O. ; McEwen, Donald G. ; Edgar, Bruce A. / Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut. In: Cell. 2009 ; Vol. 137, No. 7. pp. 1343-1355.
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