Cytotoxic dammarane glycosides from processed ginseng

Il Ho Park; Long Zhu Piao; Sung Won Kwon; Yong Jae Lee; Sool Yeon Cho; Man Ki Park; Jeong Hill Park

doi:10.1248/cpb.50.538

Cytotoxic dammarane glycosides from processed ginseng

Il Ho Park, Long Zhu Piao, Sung Won Kwon, Yong Jae Lee, Sool Yeon Cho, Man Ki Park, Jeong Hill Park

Physiology

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg₃, Rg₅, Rk₁, Rs₅, and Rs₄ are the active principles. Their 50% growth inhibition concentration (GI₅₀) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI₅₀ of 84 μM in the same assay conditions.

Original language	English (US)
Pages (from-to)	538-540
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	4
DOIs	https://doi.org/10.1248/cpb.50.538
State	Published - Apr 2002

Keywords

Cytotoxicity
Ginsenoside
Panax ginseng

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.50.538

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abstract = "Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI50 of 84 μM in the same assay conditions.",

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AU - Park, Il Ho

AU - Piao, Long Zhu

AU - Kwon, Sung Won

AU - Lee, Yong Jae

AU - Cho, Sool Yeon

AU - Park, Man Ki

AU - Park, Jeong Hill

PY - 2002/4

Y1 - 2002/4

N2 - Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI50 of 84 μM in the same assay conditions.

AB - Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI50 of 84 μM in the same assay conditions.

KW - Cytotoxicity

KW - Ginsenoside

KW - Panax ginseng

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EP - 540

JO - Chemical and Pharmaceutical Bulletin

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Cytotoxic dammarane glycosides from processed ginseng

Abstract

Keywords

ASJC Scopus subject areas

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