Cytotoxic dammarane glycosides from processed ginseng

Il Ho Park, Long Zhu Piao, Sung Won Kwon, Yong Jae Lee, Sool Yeon Cho, Man Ki Park, Jeong Hill Park

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 μM, respectively. Cisplatin had a GI50 of 84 μM in the same assay conditions.

Original languageEnglish (US)
Pages (from-to)538-540
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2002

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Keywords

  • Cytotoxicity
  • Ginsenoside
  • Panax ginseng

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Cite this

Park, I. H., Piao, L. Z., Kwon, S. W., Lee, Y. J., Cho, S. Y., Park, M. K., & Park, J. H. (2002). Cytotoxic dammarane glycosides from processed ginseng. Chemical and Pharmaceutical Bulletin, 50(4), 538-540. https://doi.org/10.1248/cpb.50.538