Abstract
Spleen cells sensitized against trinitrophenyl (TNP)-modified stimulator cells displayed a cytotoxic effect against syngeneic TNP-modified but not dinitrophenyl (DNP)-modified target cells. The same finding was observed in the opposite direction; that is, effector cells sensitized against DNP-modified stimulator cells did not cross kill TNP-modified targets. The specificity of the anti-TNP effector cells was confirmed in a cold target competition assay. Presensitization in vivo with hapten-modified cells followed by rechallenge and testing in vitro did not alter the specificity of the response between the haptens. These data indicate that the receptor(s) on the cytotoxic T cell can distinguish between two closely related haptenic molecules.
Original language | English (US) |
---|---|
Pages (from-to) | 600-605 |
Number of pages | 6 |
Journal | Journal of Experimental Medicine |
Volume | 146 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1 1977 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology