TY - JOUR
T1 - D-MEF2
T2 - A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
AU - Lilly, Brenda
AU - Galewsky, Samuel
AU - Firulli, Anthony B.
AU - Schulz, Robert A.
AU - Olson, Eric N.
PY - 1994/6/7
Y1 - 1994/6/7
N2 - The myocyte enhancer factor (MEF) 2 family of transcription factors has been implicated in the regulation of muscle transcription in vertebrates. We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum- response factor) domains of the vertebrate MEF2 proteins. D-mef2 gene expression is first detected during Drosophila embryogenesis within mesodermal precursor cells prior to specification of the somatic and visceral muscle lineages. Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development. D-mef2 expression precedes that of the MyoD homologue, nautilus, and, in contrast to nautilus, D-mef2 appears to be expressed in all somatic and visceral muscle cell precursors. Its temporal and spatial expression patterns suggest that D- mef2 may play an important role in commitment of mesoderm to myogenic lineages.
AB - The myocyte enhancer factor (MEF) 2 family of transcription factors has been implicated in the regulation of muscle transcription in vertebrates. We have cloned a protein from Drosophila, termed D-MEF2, that shares extensive amino acid homology with the MADS (MCM1, Agamous, Deficiens, and serum- response factor) domains of the vertebrate MEF2 proteins. D-mef2 gene expression is first detected during Drosophila embryogenesis within mesodermal precursor cells prior to specification of the somatic and visceral muscle lineages. Expression of D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development. D-mef2 expression precedes that of the MyoD homologue, nautilus, and, in contrast to nautilus, D-mef2 appears to be expressed in all somatic and visceral muscle cell precursors. Its temporal and spatial expression patterns suggest that D- mef2 may play an important role in commitment of mesoderm to myogenic lineages.
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U2 - 10.1073/pnas.91.12.5662
DO - 10.1073/pnas.91.12.5662
M3 - Article
C2 - 8202544
AN - SCOPUS:0028229168
SN - 0027-8424
VL - 91
SP - 5662
EP - 5666
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 12
ER -