TY - JOUR
T1 - daf-16
T2 - An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
AU - Lin, Kui
AU - Dorman, Jennie B.
AU - Rodan, Aylin
AU - Kenyon, Cynthia
PY - 1997/11/14
Y1 - 1997/11/14
N2 - The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16, daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.
AB - The wild-type Caenorhabditis elegans nematode ages rapidly, undergoing development, senescence, and death in less than 3 weeks. In contrast, mutants with reduced activity of the gene daf-2, a homolog of the insulin and insulin-like growth factor receptors, age more slowly than normal and live more than twice as long. These mutants are active and fully fertile and have normal metabolic rates. The life-span extension caused by daf-2 mutations requires the activity of the gene daf-16, daf-16 appears to play a unique role in life-span regulation and encodes a member of the hepatocyte nuclear factor 3 (HNF-3)/forkhead family of transcriptional regulators. In humans, insulin down-regulates the expression of certain genes by antagonizing the activity of HNF-3, raising the possibility that aspects of this regulatory system have been conserved.
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U2 - 10.1126/science.278.5341.1319
DO - 10.1126/science.278.5341.1319
M3 - Article
C2 - 9360933
AN - SCOPUS:0030657540
SN - 0036-8075
VL - 278
SP - 1319
EP - 1322
JO - Science
JF - Science
IS - 5341
ER -