Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury

Paul B. Comish, Deborah Carlson, Rui Kang, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

Abstract

Thermal injury is often associated with a proinflammatory state resulting in serious complications. After a burn, the innate immune system is activated with subsequent immune cell infiltration and cytokine production. Although the innate immune response is typically beneficial, an excessive activation leads to cytokine storms, multiple organ failure, and even death. This overwhelming immune response is regulated by damage-associated molecular patterns (DAMPs). DAMPs are endogenous molecules that are actively secreted by immune cells or passively released by dead or dying cells that can bind to pathogen recognition receptors in immune and nonimmune cells. Recent studies involving animal models along with human studies have drawn great attention to the possible pathological role of DAMPs as an immune consequence of thermal injury. In this review, we outline DAMPs and their function in thermal injury, shedding light on the mechanism of sterile inflammation during tissue injury and identifying new immune targets for treating thermal injury. The Journal of Immunology, 2020, 205: 1189-1197.

Original languageEnglish (US)
Pages (from-to)1189-1197
Number of pages9
JournalJournal of Immunology
Volume205
Issue number5
DOIs
StatePublished - Sep 1 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Damage-associated molecular patterns and the systemic immune consequences of severe thermal injury'. Together they form a unique fingerprint.

Cite this