DAMPs and autophagy: Cellular adaptation to injury and unscheduled cell death

Qiuhong Zhang, Rui Kang, Herbert J. Zeh, Michael T. Lotze, Daolin Tang

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Autophagy is a lysosome-mediated catabolic process involving the degradation of intracellular contents (e.g., proteins and organelles) as well as invading microbes (e.g., parasites, bacteria and viruses). Multiple forms of cellular stress can stimulate this pathway, including nutritional imbalances, oxygen deprivation, immunological response, genetic defects, chromosomal anomalies and cytotoxic stress. Damageassociated molecular pattern molecules (DAMPs) are released by stressed cells undergoing autophagy or injury, and act as endogenous danger signals to regulate the subsequent inflammatory and immune response. A complex relationship exists between DAMPs and autophagy in cellular adaption to injury and unscheduled cell death. Since both autophagy and DAMPs are important for pathogenesis of human disease, it is crucial to understand how they interplay to sustain homeostasis in stressful or dangerous environments.

Original languageEnglish (US)
Pages (from-to)451-458
Number of pages8
JournalAutophagy
Volume9
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • ATP
  • Autophagy
  • DAMP
  • HMGB1
  • IL1B
  • Injury
  • Stress

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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