Data on gray matter alterations in anxious depression

Wei Peng, Zhiyun Jia, Xiaoqi Huang, Su Lui, Weihong Kuang, John A. Sweeney, Qiyong Gong

Research output: Contribution to journalArticle

Abstract

This data article provided additional data related to the research article entitled “Brain structural abnormalities in emotional regulation and sensory processing regions associated with anxious depression” Peng et al.,2019. Correlation analyses were conducted for clinical information (HAMD total, anxiety/somatization scores, HAMA total and illness duration) and identified regional gray matter volumes in all patients with anxious depression and non-anxious depression. More detailed correlation analysis was applied for each item of anxiety factor and reginal gray matter volumes to find which items were more associated with structural alterations in patients. Data showed that mean values of regional gray matter volumes in left postcentral gyrus (PCG) were positively associated with HAMD total and anxiety factor scores in anxious depression group. More detailed correlation analysis considering each item of anxiety factor revealed that, item 10 (psychic anxiety) and Item15 (hypochondriasis) were most significantly and positively associated with regional gray matter volumes in left PCG in anxious group. While HAMA scores and illness duration showed no significant correlation with any regional gray matter volume in both patient groups. Sample size matched groups were selected to explore possible replicability of imaging results. It revealed that different gray matter volumes in right inferior frontal gyrus were most robust findings among three groups. And anxious group had larger gray matter volumes in left PCG than non-anxious depression, despite of not survived after multiple comparisons corrections.

Original languageEnglish (US)
Article number104322
JournalData in Brief
Volume25
DOIs
StatePublished - Aug 1 2019
Externally publishedYes

Fingerprint

Depression
Anxiety
Somatosensory Cortex
Hypochondriasis
Gray Matter
Prefrontal Cortex
Sample Size
Research Design
Brain
Research

Keywords

  • Anxious depression
  • Gray matter
  • Non-anxious depression

ASJC Scopus subject areas

  • General

Cite this

Peng, W., Jia, Z., Huang, X., Lui, S., Kuang, W., Sweeney, J. A., & Gong, Q. (2019). Data on gray matter alterations in anxious depression. Data in Brief, 25, [104322]. https://doi.org/10.1016/j.dib.2019.104322

Data on gray matter alterations in anxious depression. / Peng, Wei; Jia, Zhiyun; Huang, Xiaoqi; Lui, Su; Kuang, Weihong; Sweeney, John A.; Gong, Qiyong.

In: Data in Brief, Vol. 25, 104322, 01.08.2019.

Research output: Contribution to journalArticle

Peng, W, Jia, Z, Huang, X, Lui, S, Kuang, W, Sweeney, JA & Gong, Q 2019, 'Data on gray matter alterations in anxious depression', Data in Brief, vol. 25, 104322. https://doi.org/10.1016/j.dib.2019.104322
Peng W, Jia Z, Huang X, Lui S, Kuang W, Sweeney JA et al. Data on gray matter alterations in anxious depression. Data in Brief. 2019 Aug 1;25. 104322. https://doi.org/10.1016/j.dib.2019.104322
Peng, Wei ; Jia, Zhiyun ; Huang, Xiaoqi ; Lui, Su ; Kuang, Weihong ; Sweeney, John A. ; Gong, Qiyong. / Data on gray matter alterations in anxious depression. In: Data in Brief. 2019 ; Vol. 25.
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