DCC proteins: A novel family of thiol-disulfide oxidoreductases

Krzysztof Ginalski, Lisa Kinch, Leszek Rychlewski, Nick V. Grishin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Using top-of-the-range fold-recognition methods, we have assigned a thioredoxin-like structure to a family of previously uncharacterized hypothetical proteins of bacterial origin. The DCC family, named after the conserved N-terminal DxxCxxC motif, encompasses proteins of unknown function from DUF393 (in Pfam database) and COG3011. The presence of two invariant potentially catalytic cysteine residues indicates that DCC proteins function as thiol-disulfide oxidoreductases.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalTrends in Biochemical Sciences
Volume29
Issue number7
DOIs
StatePublished - Jul 2004

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Protein Disulfide Reductase (Glutathione)
Amino Acid Motifs
Thioredoxins
Bacterial Proteins
Staphylococcal Protein A
Cysteine
Databases
Proteins

ASJC Scopus subject areas

  • Biochemistry

Cite this

DCC proteins : A novel family of thiol-disulfide oxidoreductases. / Ginalski, Krzysztof; Kinch, Lisa; Rychlewski, Leszek; Grishin, Nick V.

In: Trends in Biochemical Sciences, Vol. 29, No. 7, 07.2004, p. 339-342.

Research output: Contribution to journalArticle

Ginalski, Krzysztof ; Kinch, Lisa ; Rychlewski, Leszek ; Grishin, Nick V. / DCC proteins : A novel family of thiol-disulfide oxidoreductases. In: Trends in Biochemical Sciences. 2004 ; Vol. 29, No. 7. pp. 339-342.
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