Declarative memory in patients with bipolar disorder and stimulant abuse receiving lamotrigine

I. Julian Osuji, Elizabeth Tucker, E. Sherwood Brown

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Bipolar disorder (BPD) and stimulant use are both associated with cognitive deficits. Patients with BPD and substance use disorders have poorer cognition than patients with only BPD. No longitudinal studies have examined the impact of improvement in mood and reduction in substance use on cognition, specifically memory, in patients with BPD and substance abuse. We previously reported positive effects of lamotrigine on mood and drug use in patients with BPD and stimulant dependence. In a consecutive subset of these patients, declarative memory was assessed at baseline and at week 12. Lamotrigine titration up to 300 mg/day was accomplished over 10 weeks. Participants (n = 31) with BPD and cocaine/amphetamine dependence were assessed using the Mini International Neuropsychiatric Interview, Hamilton Rating Scale for Depression, Young Mania Rating Scale, Brief Psychiatric Rating Scale, Cocaine Craving Questionnaire, and Rey Auditory Verbal Learning Test (RAVLT) while receiving lamotrigine. Drug use was assessed through urine drug screens and self-report. Mood and drug use were assessed biweekly. Psychiatric symptoms improved and drug use decreased, but performance on the RAVLT, a measure of declarative memory, declined, primarily because patients were receiving concomitant psychotropic medications. Those receiving lamotrigine monotherapy showed little change in RAVLT scores. In summary, memory deficits in patients with BPD and stimulant dependence did not improve following reduction in drug use and improvement of mood. The combination of lamotrigine with other psychotropic medications may be associated with a decline in declarative memory performance in some persons.

Original languageEnglish (US)
Pages (from-to)303-313
Number of pages11
JournalJournal of Dual Diagnosis
Volume4
Issue number3
DOIs
StatePublished - Jul 22 2008

Fingerprint

Bipolar Disorder
Verbal Learning
Pharmaceutical Preparations
Cognition
Substance-Related Disorders
Amphetamine-Related Disorders
Brief Psychiatric Rating Scale
Cocaine-Related Disorders
lamotrigine
Memory Disorders
Cocaine
Self Report
Psychiatry
Longitudinal Studies
Urine
Interviews
Depression

Keywords

  • Bipolar disorder
  • Cocaine
  • Cognition
  • Lamotrigine
  • Memory

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Declarative memory in patients with bipolar disorder and stimulant abuse receiving lamotrigine. / Osuji, I. Julian; Tucker, Elizabeth; Brown, E. Sherwood.

In: Journal of Dual Diagnosis, Vol. 4, No. 3, 22.07.2008, p. 303-313.

Research output: Contribution to journalArticle

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