Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients

Justin J. Elhoff; Shahryar M. Chowdhury; Carolyn L. Taylor; Marc Hassid; Andrew J. Savage; Andrew M. Atz; Ryan J. Butts

doi:10.1111/petr.12825

Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients

Justin J. Elhoff, Shahryar M. Chowdhury, Carolyn L. Taylor, Marc Hassid, Andrew J. Savage, Andrew M. Atz, Ryan J. Butts

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (−4.2% ±1.2, P <.01) and RV FAC (−0.05 ± 0.02, P =.04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P =.1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.

Original language	English (US)
Pages (from-to)	1106-1110
Number of pages	5
Journal	Pediatric Transplantation
Volume	20
Issue number	8
DOIs	https://doi.org/10.1111/petr.12825
State	Published - Dec 1 2016

Keywords

anesthesia
cardiac function
echocardiography
graft function
pediatric heart transplant

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Transplantation

Access to Document

10.1111/petr.12825

Cite this

@article{ecb959fdf8df47e09bd13102dd15b637,

title = "Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients",

abstract = "Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (−4.2% ±1.2, P <.01) and RV FAC (−0.05 ± 0.02, P =.04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P =.1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.",

keywords = "anesthesia, cardiac function, echocardiography, graft function, pediatric heart transplant",

author = "Elhoff, {Justin J.} and Chowdhury, {Shahryar M.} and Taylor, {Carolyn L.} and Marc Hassid and Savage, {Andrew J.} and Atz, {Andrew M.} and Butts, {Ryan J.}",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",

year = "2016",

month = dec,

day = "1",

doi = "10.1111/petr.12825",

language = "English (US)",

volume = "20",

pages = "1106--1110",

journal = "Pediatric Transplantation",

issn = "1397-3142",

publisher = "Wiley-Blackwell",

number = "8",

}

TY - JOUR

T1 - Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients

AU - Elhoff, Justin J.

AU - Chowdhury, Shahryar M.

AU - Taylor, Carolyn L.

AU - Hassid, Marc

AU - Savage, Andrew J.

AU - Atz, Andrew M.

AU - Butts, Ryan J.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (−4.2% ±1.2, P <.01) and RV FAC (−0.05 ± 0.02, P =.04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P =.1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.

AB - Echocardiography is frequently performed under anesthesia during procedures such as cardiac catheterization with EMB in pediatric HTx recipients. Anesthetic agents may depress ventricular function, resulting in concern for rejection. The aim of this study was to compare ventricular function as measured by echocardiography before and during GA in 17 pediatric HTx recipients. Nearly all markers of ventricular systolic function were significantly decreased under GA, including EF (−4.2% ±1.2, P <.01) and RV FAC (−0.05 ± 0.02, P =.04). Subjects in the first post-transplant year (n = 9) trended toward a more significant decrease in EF vs those beyond the first post-transplant year (n = 8; −6.0% ±1.2 vs −2.1 ± 2.0, P =.1). This information quantifies a decline in biventricular function that should be expected in pediatric HTx recipients while under GA and can assist the transplant clinician in avoiding unnecessary treatment of transient GA-induced ventricular dysfunction.

KW - anesthesia

KW - cardiac function

KW - echocardiography

KW - graft function

KW - pediatric heart transplant

UR - http://www.scopus.com/inward/record.url?scp=84996567001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996567001&partnerID=8YFLogxK

U2 - 10.1111/petr.12825

DO - 10.1111/petr.12825

M3 - Article

C2 - 27796066

AN - SCOPUS:84996567001

SN - 1397-3142

VL - 20

SP - 1106

EP - 1110

JO - Pediatric Transplantation

JF - Pediatric Transplantation

IS - 8

ER -

Decline in ventricular function as a result of general anesthesia in pediatric heart transplant recipients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this