Decoding the Hedgehog signal in animal development

J. Jia, J. Jiang

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

The Hedgehog (Hh) family of secreted proteins plays essential roles in a myriad of developmental processes via a complex signaling cascade conserved in species ranging from insects to mammals. In many developmental contexts, Hh acts as long-range morphogen to control distinct cellular outcomes as a function of its concentration. Here we review the current understanding of the Hh signaling mechanisms that govern the establishment of the Hh gradient and the transduction of the Hh signal with an emphasis on the intracellular signaling cascade from the receptor to the nuclear effector. We discuss how graded Hh signals are transduced to govern distinct developmental outcomes.

Original languageEnglish (US)
Pages (from-to)1249-1265
Number of pages17
JournalCellular and Molecular Life Sciences
Volume63
Issue number11
DOIs
Publication statusPublished - Jun 2006

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Keywords

  • Ci/Gli transcription factor
  • Development
  • Hedgehog signaling
  • Kinase
  • Patched
  • Pattern formation
  • Smoothened
  • Wnt

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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