Deconstructing the LDL receptor - A rhapsody in pieces

Research output: Contribution to journalShort surveypeer-review

15 Scopus citations

Abstract

The LDL receptor plays a central role in the control of plasma cholesterol levels and the prevention of coronary artery disease. Recent studies now shed light on the structural organization of several independently folded modules and domains from which the receptor is assembled, providing substantial insights into the mechanics of receptor function and the consequences of disease causing mutations.

Original languageEnglish (US)
Pages (from-to)476-478
Number of pages3
JournalNature Structural Biology
Volume8
Issue number6
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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