Decrease in mortality by propranolol in patients with heart disease and complex ventricular arrhythmias is more an anti-ischemic than an antiarrhythmic effect

Wilbert S. Aronow, Chul Ahn, Anthony D. Mercando, Stanley Epstein, Itzhak Kronzon

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We reported in a prospective, randomized study of 245 patients (mean age 81 years) with heart disease, complex ventricular arrhythmias, and a left ventricular ejection fraction of ≥40% that, compared with no antiarrhythmic drug, propranolol caused a 47% significant decrease in sudden cardiac death, a 37% significant decrease in total cardiac death, and a 20% insignificant decrease in total death.1 Follow-up 24-hour ambulatory electrocardiograms were obtained in 112 of 123 patients (91%) treated with propranolol and in 109 of 122 patients (89%) treated with no antiarrhythmic drug. This article presents data correlating the reduction in mortality by propranolol with reduction in complex ventricular arrhythmias and in abolition of myocardial ischemia.

Original languageEnglish (US)
Pages (from-to)613-615
Number of pages3
JournalThe American Journal of Cardiology
Volume74
Issue number6
DOIs
StatePublished - Sep 15 1994

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Propranolol
Cardiac Arrhythmias
Heart Diseases
Anti-Arrhythmia Agents
Mortality
Sudden Cardiac Death
Stroke Volume
Myocardial Ischemia
Electrocardiography
Prospective Studies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Decrease in mortality by propranolol in patients with heart disease and complex ventricular arrhythmias is more an anti-ischemic than an antiarrhythmic effect. / Aronow, Wilbert S.; Ahn, Chul; Mercando, Anthony D.; Epstein, Stanley; Kronzon, Itzhak.

In: The American Journal of Cardiology, Vol. 74, No. 6, 15.09.1994, p. 613-615.

Research output: Contribution to journalArticle

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