Decreased BOLD functional MR activation of the motor and sensory cortices adjacent to a glioblastoma multiforme: Implications for image-guided neurosurgery

Andrei I. Holodny, Michael Schulder, Wen Ching Liu, Joseph A Maldjian, Andrew J. Kalnin

Research output: Contribution to journalArticle

118 Scopus citations


A patient with a glioblastoma multiforme and mild sensorimotor deficits had significantly less activation of the motor and sensory cortices on the side with the tumor than on the contralateral side on blood oxygen level- dependent (BOLD) functional MR images. This difference, which may be due to pressure effects or loss of vascular autoregulation, should be considered in preoperative planning in which BOLD functional MR imaging is used to identify eloquent cortices to be avoided during brain tumor surgery.

Original languageEnglish (US)
Pages (from-to)609-612
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number4
StatePublished - Dec 1 1999


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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