Decreased creatine kinase activity in cultured Duchenne dystrophic muscle cells

S. T. Iannaccone, B. Nagy, F. J. Samaha

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Muscle cells were cultivated from six patients with Duchenne muscular dystrophy and nine normal subjects. Protein and myosin content and pyruvate kinase (PK) activity were similar in normal and Duchenne muscular dystrophy cultures. Creatine kinase (CK) activity was lower in Duchenne muscular dystrophy cultures and the isoenzyme distribution indicated MB-CK was significantly lower, while BB-CK was significantly higher in later Duchenne muscular dystrophy cultures. This abnormal isoenzyme pattern suggested aberrant or impaired maturation of Duchenne muscular dystrophy myotubes in vitro.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Child Neurology
Volume2
Issue number1
StatePublished - 1987

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Duchenne Muscular Dystrophy
Creatine Kinase
Muscle Cells
Isoenzymes
BB Form Creatine Kinase
Myosin-Light-Chain Kinase
MB Form Creatine Kinase
Pyruvate Kinase
Skeletal Muscle Fibers
Proteins

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Decreased creatine kinase activity in cultured Duchenne dystrophic muscle cells. / Iannaccone, S. T.; Nagy, B.; Samaha, F. J.

In: Journal of Child Neurology, Vol. 2, No. 1, 1987, p. 17-21.

Research output: Contribution to journalArticle

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