Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis

Carla García, Alejandra Soriano-Fallas, Juanita Lozano, Nora Leos, Ana M. Gomez, Octavio Ramilo, Asuncion Mejias

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

The immunopathogenesis of respiratory syncytial virus (RSV) and human rhinovirus lower respiratory tract infections in children remains to be defined. We measured nasal wash concentrations of 29 cytokines in infants with RSV or human rhinovirus lower respiratory tract infections. Concentrations of interferon-γ in RSV and innate immunity cytokines in both infections inversely correlated with disease severity.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalPediatric Infectious Disease Journal
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Bronchiolitis
  • HRV
  • RSV
  • cytokines
  • disease severity
  • innate immunity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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