Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer

Xin Wang, Ming Ming Cui, Yangyang Xu, Li Liu, Ye Niu, Tiemin Liu, Zhi Ping Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Altered mean platelet volume (MPV) is implicated in a wide range of cancers. However, the prognostic role of MPV in muscle-invasive bladder cancer (MIBC) remains largely unknown. The purpose of this study was to elucidate the predictive significance of MPV in MIBC. Method: The retrospective study included 218 consecutive MIBC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Result: Of the 218 patients, low MPV levels were detected in 141 (64.7 %) patients. Reduced MPV was associated with T stage and histology grade (p < 0.05). In the Kaplan-Meier analysis, decreased MPV was significantly associated with a poorer overall survival (p = 0.007). In the multivariate Cox model, decreased MPV was an independent prognostic index for overall survival (HR=2.023, 95% CI=1.050-3.897, p = 0.025). Conclusion: MPV is easily available in routine blood test. Our results demonstrated that reduced MPV could be regarded as a potential prognosis indicator for clinical outcome in MIBC.

Original languageEnglish (US)
Pages (from-to)68115-68122
Number of pages8
JournalOncotarget
Volume8
Issue number40
DOIs
StatePublished - Jul 12 2017

Keywords

  • Bladder cancer
  • Mean platelet volume
  • Prognosis

ASJC Scopus subject areas

  • Oncology

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