Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer

Xin Wang; Ming Ming Cui; Yangyang Xu; Li Liu; Ye Niu; Tiemin Liu; Zhi Ping Liu; Rui Tao Wang; Kai Jiang Yu

doi:10.18632/oncotarget.19242

Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer

Xin Wang, Ming Ming Cui, Yangyang Xu, Li Liu, Ye Niu, Tiemin Liu, Zhi Ping Liu, Rui Tao Wang, Kai Jiang Yu

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Background: Altered mean platelet volume (MPV) is implicated in a wide range of cancers. However, the prognostic role of MPV in muscle-invasive bladder cancer (MIBC) remains largely unknown. The purpose of this study was to elucidate the predictive significance of MPV in MIBC. Method: The retrospective study included 218 consecutive MIBC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Result: Of the 218 patients, low MPV levels were detected in 141 (64.7 %) patients. Reduced MPV was associated with T stage and histology grade (p < 0.05). In the Kaplan-Meier analysis, decreased MPV was significantly associated with a poorer overall survival (p = 0.007). In the multivariate Cox model, decreased MPV was an independent prognostic index for overall survival (HR=2.023, 95% CI=1.050-3.897, p = 0.025). Conclusion: MPV is easily available in routine blood test. Our results demonstrated that reduced MPV could be regarded as a potential prognosis indicator for clinical outcome in MIBC.

Original language	English (US)
Pages (from-to)	68115-68122
Number of pages	8
Journal	Oncotarget
Volume	8
Issue number	40
DOIs	https://doi.org/10.18632/oncotarget.19242
State	Published - Jul 12 2017

Keywords

Bladder cancer
Mean platelet volume
Prognosis

ASJC Scopus subject areas

Oncology

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10.18632/oncotarget.19242

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title = "Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer",

abstract = "Background: Altered mean platelet volume (MPV) is implicated in a wide range of cancers. However, the prognostic role of MPV in muscle-invasive bladder cancer (MIBC) remains largely unknown. The purpose of this study was to elucidate the predictive significance of MPV in MIBC. Method: The retrospective study included 218 consecutive MIBC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Result: Of the 218 patients, low MPV levels were detected in 141 (64.7 %) patients. Reduced MPV was associated with T stage and histology grade (p < 0.05). In the Kaplan-Meier analysis, decreased MPV was significantly associated with a poorer overall survival (p = 0.007). In the multivariate Cox model, decreased MPV was an independent prognostic index for overall survival (HR=2.023, 95% CI=1.050-3.897, p = 0.025). Conclusion: MPV is easily available in routine blood test. Our results demonstrated that reduced MPV could be regarded as a potential prognosis indicator for clinical outcome in MIBC.",

keywords = "Bladder cancer, Mean platelet volume, Prognosis",

author = "Xin Wang and Cui, {Ming Ming} and Yangyang Xu and Li Liu and Ye Niu and Tiemin Liu and Liu, {Zhi Ping} and Wang, {Rui Tao} and Yu, {Kai Jiang}",

note = "Funding Information: This work was supported financially by grants from the Harbin Medical University Cancer Hospital (JJZD2017-05) and postdoctoral research project of Heilongjiang Province (No. LBH-Z16190). Publisher Copyright: {\textcopyright} 2017 Impact Journals LLC. All rights reserved.",

year = "2017",

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doi = "10.18632/oncotarget.19242",

language = "English (US)",

volume = "8",

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T1 - Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer

AU - Wang, Xin

AU - Cui, Ming Ming

AU - Xu, Yangyang

AU - Liu, Li

AU - Niu, Ye

AU - Liu, Tiemin

AU - Liu, Zhi Ping

AU - Wang, Rui Tao

AU - Yu, Kai Jiang

N1 - Funding Information: This work was supported financially by grants from the Harbin Medical University Cancer Hospital (JJZD2017-05) and postdoctoral research project of Heilongjiang Province (No. LBH-Z16190). Publisher Copyright: © 2017 Impact Journals LLC. All rights reserved.

PY - 2017/7/12

Y1 - 2017/7/12

N2 - Background: Altered mean platelet volume (MPV) is implicated in a wide range of cancers. However, the prognostic role of MPV in muscle-invasive bladder cancer (MIBC) remains largely unknown. The purpose of this study was to elucidate the predictive significance of MPV in MIBC. Method: The retrospective study included 218 consecutive MIBC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Result: Of the 218 patients, low MPV levels were detected in 141 (64.7 %) patients. Reduced MPV was associated with T stage and histology grade (p < 0.05). In the Kaplan-Meier analysis, decreased MPV was significantly associated with a poorer overall survival (p = 0.007). In the multivariate Cox model, decreased MPV was an independent prognostic index for overall survival (HR=2.023, 95% CI=1.050-3.897, p = 0.025). Conclusion: MPV is easily available in routine blood test. Our results demonstrated that reduced MPV could be regarded as a potential prognosis indicator for clinical outcome in MIBC.

AB - Background: Altered mean platelet volume (MPV) is implicated in a wide range of cancers. However, the prognostic role of MPV in muscle-invasive bladder cancer (MIBC) remains largely unknown. The purpose of this study was to elucidate the predictive significance of MPV in MIBC. Method: The retrospective study included 218 consecutive MIBC patients between January 2009 and December 2009. The relationships between MPV and clinicopathological characteristics were analyzed. Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. Result: Of the 218 patients, low MPV levels were detected in 141 (64.7 %) patients. Reduced MPV was associated with T stage and histology grade (p < 0.05). In the Kaplan-Meier analysis, decreased MPV was significantly associated with a poorer overall survival (p = 0.007). In the multivariate Cox model, decreased MPV was an independent prognostic index for overall survival (HR=2.023, 95% CI=1.050-3.897, p = 0.025). Conclusion: MPV is easily available in routine blood test. Our results demonstrated that reduced MPV could be regarded as a potential prognosis indicator for clinical outcome in MIBC.

KW - Bladder cancer

KW - Mean platelet volume

KW - Prognosis

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Decreased mean platelet volume predicts poor prognosis in invasive bladder cancer

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