Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training

Go Suzuki, Shinichi Tokuno, Masashi Nibuya, Toru Ishida, Tetsuo Yamamoto, Yasuo Mukai, Keiji Mitani, Gentaro Tsumatori, Daniel Scott, Kunio Shimizu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Decreased concentrations of plasma brain-derived neurotrophic factor (BDNF) and serum BDNF have been proposed to be a state marker of depression and a biological indicator of loaded psychosocial stress. Stress evaluations of participants in military mission are critically important and appropriate objective biological parameters that evaluate stress are needed. In military circumstances, there are several problems to adopt plasma BDNF concentration as a stress biomarker. First, in addition to psychosocial stress, military missions inevitably involve physical exercise that increases plasma BDNF concentrations. Second, most participants in the mission do not have adequate quality or quantity of sleep, and sleep deprivation has also been reported to increase plasma BDNF concentration. We evaluated plasma BDNF concentrations in 52 participants on a 9-week military mission. The present study revealed that plasma BDNF concentration significantly decreased despite elevated serum enzymes that escaped from muscle and decreased quantity and quality of sleep, as detected by a wearable watch-type sensor. In addition, we observed a significant decrease in plasma vascular endothelial growth factor (VEGF) during the mission. VEGF is also neurotrophic and its expression in the brain has been reported to be up-regulated by antidepressive treatments and down-regulated by stress. This is the first report of decreased plasma VEGF concentrations by stress. We conclude that decreased plasma concentrations of neurotrophins can be candidates for mental stress indicators in actual stressful environments that include physical exercise and limited sleep.

Original languageEnglish (US)
Article numbere89455
JournalPloS one
Volume9
Issue number2
DOIs
StatePublished - Feb 24 2014
Externally publishedYes

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neurotrophins
vascular endothelial growth factors
Brain-Derived Neurotrophic Factor
Vascular Endothelial Growth Factor A
brain
Plasmas
sleep
Sleep
exercise
Exercise
Sleep Deprivation
Watches
Nerve Growth Factors
Biomarkers
Serum
biomarkers
Muscle
Brain
muscles
Depression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training. / Suzuki, Go; Tokuno, Shinichi; Nibuya, Masashi; Ishida, Toru; Yamamoto, Tetsuo; Mukai, Yasuo; Mitani, Keiji; Tsumatori, Gentaro; Scott, Daniel; Shimizu, Kunio.

In: PloS one, Vol. 9, No. 2, e89455, 24.02.2014.

Research output: Contribution to journalArticle

Suzuki, G, Tokuno, S, Nibuya, M, Ishida, T, Yamamoto, T, Mukai, Y, Mitani, K, Tsumatori, G, Scott, D & Shimizu, K 2014, 'Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training', PloS one, vol. 9, no. 2, e89455. https://doi.org/10.1371/journal.pone.0089455
Suzuki, Go ; Tokuno, Shinichi ; Nibuya, Masashi ; Ishida, Toru ; Yamamoto, Tetsuo ; Mukai, Yasuo ; Mitani, Keiji ; Tsumatori, Gentaro ; Scott, Daniel ; Shimizu, Kunio. / Decreased plasma brain-derived neurotrophic factor and vascular endothelial growth factor concentrations during military training. In: PloS one. 2014 ; Vol. 9, No. 2.
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