Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus

Do June Min; Mi La Cho; Chul Soo Cho; So Youn Min; Wan Uk Kim; Si Young Yang; Jun Ki Min; Yeon Sik Hong; Sang Heon Lee; Sung Hwan Park; Ho Youn Kim

doi:10.1080/030097401300162932

Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus

Do June Min, Mi La Cho, Chul Soo Cho, So Youn Min, Wan Uk Kim, Si Young Yang, Jun Ki Min, Yeon Sik Hong, Sang Heon Lee, Sung Hwan Park, Ho Youn Kim

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Objective. To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status. Methods. We measured the serum levels of type 1 (IFN-γ, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE. Results. Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-γ than those without LN. Production of IL-12 and IFN-γ by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-γ, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-γ levels. Conclusion. The reduced production of IL-12 and IFN-γ and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.

Original language	English (US)
Pages (from-to)	159-163
Number of pages	5
Journal	Scandinavian Journal of Rheumatology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1080/030097401300162932
State	Published - 2001

Keywords

Disease activity
Interferon-γ
Interleukin-12
Lupus nephritis
Systemic lupus erythematosus
Type 2 cytokine

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

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10.1080/030097401300162932

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title = "Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus",

abstract = "Objective. To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status. Methods. We measured the serum levels of type 1 (IFN-γ, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE. Results. Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-γ than those without LN. Production of IL-12 and IFN-γ by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-γ, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-γ levels. Conclusion. The reduced production of IL-12 and IFN-γ and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.",

keywords = "Disease activity, Interferon-γ, Interleukin-12, Lupus nephritis, Systemic lupus erythematosus, Type 2 cytokine",

author = "Min, {Do June} and Cho, {Mi La} and Cho, {Chul Soo} and Min, {So Youn} and Kim, {Wan Uk} and Yang, {Si Young} and Min, {Jun Ki} and Hong, {Yeon Sik} and Lee, {Sang Heon} and Park, {Sung Hwan} and Kim, {Ho Youn}",

note = "Funding Information: This artilcwaes supported by grants from Institutes of Mediacl Sciecen.",

year = "2001",

doi = "10.1080/030097401300162932",

language = "English (US)",

volume = "30",

pages = "159--163",

journal = "Scandinavian Journal of Rheumatology",

issn = "0300-9742",

publisher = "Informa Healthcare",

number = "3",

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TY - JOUR

T1 - Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus

AU - Min, Do June

AU - Cho, Mi La

AU - Cho, Chul Soo

AU - Min, So Youn

AU - Kim, Wan Uk

AU - Yang, Si Young

AU - Min, Jun Ki

AU - Hong, Yeon Sik

AU - Lee, Sang Heon

AU - Park, Sung Hwan

AU - Kim, Ho Youn

N1 - Funding Information: This artilcwaes supported by grants from Institutes of Mediacl Sciecen.

PY - 2001

Y1 - 2001

N2 - Objective. To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status. Methods. We measured the serum levels of type 1 (IFN-γ, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE. Results. Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-γ than those without LN. Production of IL-12 and IFN-γ by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-γ, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-γ levels. Conclusion. The reduced production of IL-12 and IFN-γ and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.

AB - Objective. To analyze the type 1/type 2 cytokine balance in patients with systemic lupus erythematosus (SLE) according to the presence of renal disorder and activity status. Methods. We measured the serum levels of type 1 (IFN-γ, IL-12) and type 2 cytokines (IL-4, IL-10) as well as spontaneous and stimulated cytokine production from peripheral blood mononuclear cells (PBMC) in 40 patients with SLE. Results. Patients with lupus nephritis (LN) showed significantly lower levels of serum IL-12 and IFN-γ than those without LN. Production of IL-12 and IFN-γ by stimulated PBMC were also decreased in patients with LN. The circulating IL-12 correlated positively with IFN-γ, but inversely with IL-10. The SLEDAI scores correlated well with the ratio of IL-4/IFN-γ levels. Conclusion. The reduced production of IL-12 and IFN-γ and the resultant shift towards the type 2 cytokine phenotype may be associated with LN.

KW - Disease activity

KW - Interferon-γ

KW - Interleukin-12

KW - Lupus nephritis

KW - Systemic lupus erythematosus

KW - Type 2 cytokine

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Decreased production of interleukin-12 and interferon-γ is associated with renal involvement in systemic lupus erythematosus

Abstract

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