Decreased risk of celiac disease in patients with helicobacter pylori colonization

Benjamin Lebwohl, Martin J. Blaser, Jonas F. Ludvigsson, Peter H R Green, Andrew Rundle, Amnon Sonnenberg, Robert M. Genta

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

The prevalence of celiac disease (CD) has increased in recent decades without a clear explanation. The "hygiene hypothesis" theorizes that decreased exposure to bacterial antigens may trigger autoimmunity. We aimed to determine whether Helicobacter pylori infection and CD were associated among patients undergoing upper gastrointestinal endoscopy. We performed a cross-sectional study of patients who underwent esophagogastroduodenoscopy with submission of gastric and duodenal biopsies to Miraca Life Sciences, Inc. (Irving, Texas), a US commercial pathology laboratory, during a 4.5-year period (January 2008-June 2012). We compared the prevalence of H. pylori in CD patients with that in persons without CD. We performed multiple logistic regression analysis, adjusting odds ratios for patient age, gender, and racial, ethnic, and socioeconomic factors. Among 136,179 patients, a total of 2,689 (2.0%) had CD. H. pylori prevalence was significantly lower in patients with CD (4.4%) than in those without CD (8.8%; P < 0.0001). After adjustment for the above covariates, this inverse relationship remained strong (adjusted odds ratio (OR) = 0.48, 95% confidence interval (CI): 0.40, 0.58). The relationships were similar in men (unadjusted OR = 0.51, 95% CI: 0.38, 0.69) and women (unadjusted OR = 0.46, 95% CI: 0.36, 0.58) and in all age groups. We conclude that H. pylori presence and CD are inversely associated, a relationship that persists after adjustment for socioeconomic factors. Future studies should address whether H. pylori modulates immune responses to ingested gluten.

Original languageEnglish (US)
Pages (from-to)1721-1730
Number of pages10
JournalAmerican Journal of Epidemiology
Volume178
Issue number12
DOIs
StatePublished - Dec 1 2013

Keywords

  • Celiac disease
  • Gluten
  • Helicobacter pylori

ASJC Scopus subject areas

  • Epidemiology

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    Lebwohl, B., Blaser, M. J., Ludvigsson, J. F., Green, P. H. R., Rundle, A., Sonnenberg, A., & Genta, R. M. (2013). Decreased risk of celiac disease in patients with helicobacter pylori colonization. American Journal of Epidemiology, 178(12), 1721-1730. https://doi.org/10.1093/aje/kwt234