Decreased serum 24,25-dihydroxyvitamin D concentration during long-term anticonvulsant therapy in adult epileptics

J. E. Zerwekh, R. Homan, R. Tindall, C. Y C Pak

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22 Citations (Scopus)

Abstract

Serum concentrations of 25-hydroxyvitamin D (25-OHD), 24,25-dihydroxyvitamin D [24,25-(OH)2D], and 1α,25-dihydroxyvitamin D [1,25-(OH)2D] were measured in 30 ambulatory adult epileptic patients during long-term anticonvulsant treatment with phenytoin, phenobarbital, or carbamazepine. For the entire group, serum 24,25-(OH)2D was decreased (p < 0.0005) as compared to normal subjects to a mean value of 0.7 ± 0.1 (SEM) ng/ml. However, serum 1,25-(OH)2D was increased at 50 ± 7 pg/ml (p < 0.025). Serum 25-OHD declined insignificantly to 19 ± 3 ng.ml. All three drugs caused a significant reduction of serum 24,25-(OH)2D concentrations. A significant decrease in serum 25-OHD was observed only for the phenobarbital-treated patients. Serum 1,25-(OH)2D was high in patients receiving phenytoin or carbamazepine but not in those taking phenobarbital. The findings suggest that while various anticonvulsant drugs appear to exert different effects on vitamin D metabolism, a universal finding is diminished serum 24,25-(OH)2D. The results support the notion that 24,25-(OH)2D deficiency may play an important role in the pathogenesis of anticonvulsant-induced osteomalacia.

Original languageEnglish (US)
Pages (from-to)184-186
Number of pages3
JournalAnnals of Neurology
Volume12
Issue number2
StatePublished - 1982

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Dihydroxycholecalciferols
Anticonvulsants
Serum
Phenobarbital
Carbamazepine
Phenytoin
Therapeutics
Osteomalacia
Vitamin D

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Decreased serum 24,25-dihydroxyvitamin D concentration during long-term anticonvulsant therapy in adult epileptics. / Zerwekh, J. E.; Homan, R.; Tindall, R.; Pak, C. Y C.

In: Annals of Neurology, Vol. 12, No. 2, 1982, p. 184-186.

Research output: Contribution to journalArticle

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