Deduced primary structure of the α subunit of the GTP-binding stimulatory protein of adenylate cyclase

J. D. Robishaw, D. W. Russell, B. A. Harris, M. D. Smigel, A. G. Gilman

Research output: Contribution to journalArticle

109 Scopus citations


A bovine adrenal cDNA clone encoding the entire α subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (G(s)) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of G(sα) with the α subunit of another G protein, transducin, revealed striking homologies.

Original languageEnglish (US)
Pages (from-to)1251-1255
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number5
StatePublished - Jan 1 1986


ASJC Scopus subject areas

  • General

Cite this