Deduced primary structure of the α subunit of the GTP-binding stimulatory protein of adenylate cyclase

J. D. Robishaw, D. W. Russell, B. A. Harris, M. D. Smigel, A. G. Gilman

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

A bovine adrenal cDNA clone encoding the entire α subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (G(s)) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of G(sα) with the α subunit of another G protein, transducin, revealed striking homologies.

Original languageEnglish (US)
Pages (from-to)1251-1255
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number5
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • General

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