A bovine adrenal cDNA clone encoding the entire α subunit of the GTP-binding regulatory protein that stimulates adenylate cyclase (G(s)) was isolated and sequenced. This cDNA directed the synthesis of the larger, 52-kDa form of the polypeptide in COS cells, even though the clone appeared to encode a 46-kDa protein. Comparison of the deduced amino acid sequence of G(sα) with the α subunit of another G protein, transducin, revealed striking homologies.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Jan 1 1986|
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