Deep Brain Stimulation for Depression Informed by Intracranial Recordings

Sameer A. Sheth; Kelly R. Bijanki; Brian Metzger; Anusha Allawala; Victoria Pirtle; Joshua A. Adkinson; John Myers; Raissa K. Mathura; Denise Oswalt; Evangelia Tsolaki; Jiayang Xiao; Angela Noecker; Adriana M. Strutt; Jeffrey F. Cohn; Cameron C. McIntyre; Sanjay J. Mathew; David Borton; Wayne Goodman; Nader Pouratian

doi:10.1016/j.biopsych.2021.11.007

Deep Brain Stimulation for Depression Informed by Intracranial Recordings

Sameer A. Sheth, Kelly R. Bijanki, Brian Metzger, Anusha Allawala, Victoria Pirtle, Joshua A. Adkinson, John Myers, Raissa K. Mathura, Denise Oswalt, Evangelia Tsolaki, Jiayang Xiao, Angela Noecker, Adriana M. Strutt, Jeffrey F. Cohn, Cameron C. McIntyre, Sanjay J. Mathew, David Borton, Wayne Goodman, Nader Pouratian

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.

Original language	English (US)
Pages (from-to)	246-251
Number of pages	6
Journal	Biological Psychiatry
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/j.biopsych.2021.11.007
State	Published - Aug 1 2022

Keywords

Deep brain stimulation
Depression
Epilepsy
Network
Neuromodulation
Stereo-EEG

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/j.biopsych.2021.11.007

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Sheth, S. A., Bijanki, K. R., Metzger, B., Allawala, A., Pirtle, V., Adkinson, J. A., Myers, J., Mathura, R. K., Oswalt, D., Tsolaki, E., Xiao, J., Noecker, A., Strutt, A. M., Cohn, J. F., McIntyre, C. C., Mathew, S. J., Borton, D., Goodman, W., & Pouratian, N. (2022). Deep Brain Stimulation for Depression Informed by Intracranial Recordings. Biological Psychiatry, 92(3), 246-251. https://doi.org/10.1016/j.biopsych.2021.11.007

Sheth, SA, Bijanki, KR, Metzger, B, Allawala, A, Pirtle, V, Adkinson, JA, Myers, J, Mathura, RK, Oswalt, D, Tsolaki, E, Xiao, J, Noecker, A, Strutt, AM, Cohn, JF, McIntyre, CC, Mathew, SJ, Borton, D, Goodman, W & Pouratian, N 2022, 'Deep Brain Stimulation for Depression Informed by Intracranial Recordings', Biological Psychiatry, vol. 92, no. 3, pp. 246-251. https://doi.org/10.1016/j.biopsych.2021.11.007

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abstract = "The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.",

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AU - Myers, John

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AU - Xiao, Jiayang

AU - Noecker, Angela

AU - Strutt, Adriana M.

AU - Cohn, Jeffrey F.

AU - McIntyre, Cameron C.

AU - Mathew, Sanjay J.

AU - Borton, David

AU - Goodman, Wayne

AU - Pouratian, Nader

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N2 - The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.

AB - The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel inverse solution approach. In the ensuing double-blind, randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurologic and psychiatric disorders.

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Deep Brain Stimulation for Depression Informed by Intracranial Recordings

Abstract

Keywords

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