Deep Learning in Proteomics

Bo Wen, Wen Feng Zeng, Yuxing Liao, Zhiao Shi, Sara R. Savage, Wen Jiang, Bing Zhang

Research output: Contribution to journalReview articlepeer-review

Abstract

Proteomics, the study of all the proteins in biological systems, is becoming a data-rich science. Protein sequences and structures are comprehensively catalogued in online databases. With recent advancements in tandem mass spectrometry (MS) technology, protein expression and post-translational modifications (PTMs) can be studied in a variety of biological systems at the global scale. Sophisticated computational algorithms are needed to translate the vast amount of data into novel biological insights. Deep learning automatically extracts data representations at high levels of abstraction from data, and it thrives in data-rich scientific research domains. Here, a comprehensive overview of deep learning applications in proteomics, including retention time prediction, MS/MS spectrum prediction, de novo peptide sequencing, PTM prediction, major histocompatibility complex-peptide binding prediction, and protein structure prediction, is provided. Limitations and the future directions of deep learning in proteomics are also discussed. This review will provide readers an overview of deep learning and how it can be used to analyze proteomics data.

Original languageEnglish (US)
Article number1900335
JournalProteomics
Volume20
Issue number21-22
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • bioinformatics
  • deep learning
  • proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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