Defective anti-listerial responses in deciduoma of pseudopregnant mice

R. W. Redline, C. M. Shea, V. E. Papaioannou, C. Y. Lu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of Listeria monocytogenes. Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility. Anti-listerial responses in other organs were unaffected by pseudopregnancy. Animals manifesting increased susceptibility formed distinct uterine swellings in response to the combination of hormones and uterine listeria. These swellings correspond to previously described deciduoma and closely mimic the decidualized endometrium of pregnancy. The nature of the defective response to listeria was investigated by immunocytochemistry. Increased bacterial titers were correlated with an inability of macrophages and T lymphocytes to reach tissue listeria in discrete regions of deciduoma-bearing uteri. Control uteri showed a normal granulomatous pattern of inflammation. These findings closely parallel previous findings in the murine decidua basalis and suggest that properties of decidualized endometrial stromal cells regulate local immune responsiveness.

Original languageEnglish (US)
Pages (from-to)485-497
Number of pages13
JournalAmerican Journal of Pathology
Volume133
Issue number3
StatePublished - 1988

Fingerprint

Deciduoma
Listeria
Pseudopregnancy
Uterus
Decidua
Listeria monocytogenes
Stromal Cells
Endometrium
Immunohistochemistry
Macrophages
Hormones
Inflammation
T-Lymphocytes
Pregnancy
Injections

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Redline, R. W., Shea, C. M., Papaioannou, V. E., & Lu, C. Y. (1988). Defective anti-listerial responses in deciduoma of pseudopregnant mice. American Journal of Pathology, 133(3), 485-497.

Defective anti-listerial responses in deciduoma of pseudopregnant mice. / Redline, R. W.; Shea, C. M.; Papaioannou, V. E.; Lu, C. Y.

In: American Journal of Pathology, Vol. 133, No. 3, 1988, p. 485-497.

Research output: Contribution to journalArticle

Redline, RW, Shea, CM, Papaioannou, VE & Lu, CY 1988, 'Defective anti-listerial responses in deciduoma of pseudopregnant mice', American Journal of Pathology, vol. 133, no. 3, pp. 485-497.
Redline, R. W. ; Shea, C. M. ; Papaioannou, V. E. ; Lu, C. Y. / Defective anti-listerial responses in deciduoma of pseudopregnant mice. In: American Journal of Pathology. 1988 ; Vol. 133, No. 3. pp. 485-497.
@article{bcc1d82d4a464f1f878272f9d80ee312,
title = "Defective anti-listerial responses in deciduoma of pseudopregnant mice",
abstract = "Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of Listeria monocytogenes. Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility. Anti-listerial responses in other organs were unaffected by pseudopregnancy. Animals manifesting increased susceptibility formed distinct uterine swellings in response to the combination of hormones and uterine listeria. These swellings correspond to previously described deciduoma and closely mimic the decidualized endometrium of pregnancy. The nature of the defective response to listeria was investigated by immunocytochemistry. Increased bacterial titers were correlated with an inability of macrophages and T lymphocytes to reach tissue listeria in discrete regions of deciduoma-bearing uteri. Control uteri showed a normal granulomatous pattern of inflammation. These findings closely parallel previous findings in the murine decidua basalis and suggest that properties of decidualized endometrial stromal cells regulate local immune responsiveness.",
author = "Redline, {R. W.} and Shea, {C. M.} and Papaioannou, {V. E.} and Lu, {C. Y.}",
year = "1988",
language = "English (US)",
volume = "133",
pages = "485--497",
journal = "American Journal of Pathology",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Defective anti-listerial responses in deciduoma of pseudopregnant mice

AU - Redline, R. W.

AU - Shea, C. M.

AU - Papaioannou, V. E.

AU - Lu, C. Y.

PY - 1988

Y1 - 1988

N2 - Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of Listeria monocytogenes. Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility. Anti-listerial responses in other organs were unaffected by pseudopregnancy. Animals manifesting increased susceptibility formed distinct uterine swellings in response to the combination of hormones and uterine listeria. These swellings correspond to previously described deciduoma and closely mimic the decidualized endometrium of pregnancy. The nature of the defective response to listeria was investigated by immunocytochemistry. Increased bacterial titers were correlated with an inability of macrophages and T lymphocytes to reach tissue listeria in discrete regions of deciduoma-bearing uteri. Control uteri showed a normal granulomatous pattern of inflammation. These findings closely parallel previous findings in the murine decidua basalis and suggest that properties of decidualized endometrial stromal cells regulate local immune responsiveness.

AB - Two different hormonal regimens to induce pseudopregnancy resulted in a pronounced increase in the susceptibility of the murine uterus to intraluminal injections of Listeria monocytogenes. Preimmunization, which profoundly augments systemic listeria resistance, had no effect on this increased uterine susceptibility. Anti-listerial responses in other organs were unaffected by pseudopregnancy. Animals manifesting increased susceptibility formed distinct uterine swellings in response to the combination of hormones and uterine listeria. These swellings correspond to previously described deciduoma and closely mimic the decidualized endometrium of pregnancy. The nature of the defective response to listeria was investigated by immunocytochemistry. Increased bacterial titers were correlated with an inability of macrophages and T lymphocytes to reach tissue listeria in discrete regions of deciduoma-bearing uteri. Control uteri showed a normal granulomatous pattern of inflammation. These findings closely parallel previous findings in the murine decidua basalis and suggest that properties of decidualized endometrial stromal cells regulate local immune responsiveness.

UR - http://www.scopus.com/inward/record.url?scp=0024271134&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024271134&partnerID=8YFLogxK

M3 - Article

C2 - 3144175

AN - SCOPUS:0024271134

VL - 133

SP - 485

EP - 497

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 0002-9440

IS - 3

ER -