Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy

Francisco Westermeier, Mario Navarro-Marquez, Camila López-Crisosto, Roberto Bravo-Sagua, Clara Quiroga, Mario Bustamante, Hugo E. Verdejo, Ricardo Zalaquett, Mauricio Ibacache, Valentina Parra, Pablo F. Castro, Beverly A Rothermel, Joseph A Hill, Sergio Lavandero

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart. Myocardial energy metabolism depends on mitochondria, which must generate sufficient ATP to meet the high energy demands of the myocardium. Dysfunctional mitochondria are involved in the pathophysiology of diabetic heart disease. A large body of evidence implicates myocardial insulin resistance in the pathogenesis of DCM. Recent studies show that insulin signaling influences myocardial energy metabolism by impacting cardiomyocyte mitochondrial dynamics and function under physiological conditions. However, comprehensive understanding of molecular mechanisms linking insulin signaling and changes in the architecture of the mitochondrial network in diabetic cardiomyopathy is lacking. This review summarizes our current understanding of how defective insulin signaling impacts cardiac function in diabetic cardiomyopathy and discusses the potential role of mitochondrial dynamics.

Original languageEnglish (US)
Pages (from-to)1113-1118
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1853
Issue number5
DOIs
StatePublished - May 1 2015

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Diabetic Cardiomyopathies
Mitochondrial Dynamics
Insulin
Energy Metabolism
Mitochondria
Congenital Heart Defects
Cardiac Myocytes
Type 2 Diabetes Mellitus
Insulin Resistance
Heart Diseases
Myocardium
Adenosine Triphosphate

Keywords

  • Diabetic cardiomyopathy
  • Insulin signaling
  • Mitochondrial dynamics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Westermeier, F., Navarro-Marquez, M., López-Crisosto, C., Bravo-Sagua, R., Quiroga, C., Bustamante, M., ... Lavandero, S. (2015). Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy. Biochimica et Biophysica Acta - Molecular Cell Research, 1853(5), 1113-1118. https://doi.org/10.1016/j.bbamcr.2015.02.005

Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy. / Westermeier, Francisco; Navarro-Marquez, Mario; López-Crisosto, Camila; Bravo-Sagua, Roberto; Quiroga, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett, Ricardo; Ibacache, Mauricio; Parra, Valentina; Castro, Pablo F.; Rothermel, Beverly A; Hill, Joseph A; Lavandero, Sergio.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1853, No. 5, 01.05.2015, p. 1113-1118.

Research output: Contribution to journalArticle

Westermeier, F, Navarro-Marquez, M, López-Crisosto, C, Bravo-Sagua, R, Quiroga, C, Bustamante, M, Verdejo, HE, Zalaquett, R, Ibacache, M, Parra, V, Castro, PF, Rothermel, BA, Hill, JA & Lavandero, S 2015, 'Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy', Biochimica et Biophysica Acta - Molecular Cell Research, vol. 1853, no. 5, pp. 1113-1118. https://doi.org/10.1016/j.bbamcr.2015.02.005
Westermeier F, Navarro-Marquez M, López-Crisosto C, Bravo-Sagua R, Quiroga C, Bustamante M et al. Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy. Biochimica et Biophysica Acta - Molecular Cell Research. 2015 May 1;1853(5):1113-1118. https://doi.org/10.1016/j.bbamcr.2015.02.005
Westermeier, Francisco ; Navarro-Marquez, Mario ; López-Crisosto, Camila ; Bravo-Sagua, Roberto ; Quiroga, Clara ; Bustamante, Mario ; Verdejo, Hugo E. ; Zalaquett, Ricardo ; Ibacache, Mauricio ; Parra, Valentina ; Castro, Pablo F. ; Rothermel, Beverly A ; Hill, Joseph A ; Lavandero, Sergio. / Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy. In: Biochimica et Biophysica Acta - Molecular Cell Research. 2015 ; Vol. 1853, No. 5. pp. 1113-1118.
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