Defective recovery of semi-conservative DNA synthesis in xeroderma pigmentosum cells following split-dose ultraviolet irradiation

Ethel Moustacchi; Ursula K. Ehmann; Errol C. Friedberg

doi:10.1016/0027-5107(79)90229-X

Defective recovery of semi-conservative DNA synthesis in xeroderma pigmentosum cells following split-dose ultraviolet irradiation

Ethel Moustacchi, Ursula K. Ehmann, Errol C. Friedberg

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

In normal human fibroblasts we observe an enhancement of the recovery of the rate of semi-conservative DNA synthesis after split-dose UV-irradiation relative to a single total UV dose. The enhanced recovery is totally absent in both a xeroderma pigmentosum variant line and two xeroderma pigmentosum lines belonging to complementation groups A and C.

Original language	English (US)
Pages (from-to)	159-171
Number of pages	13
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	62
Issue number	1
DOIs	https://doi.org/10.1016/0027-5107(79)90229-X
State	Published - Aug 1979

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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Defective recovery of semi-conservative DNA synthesis in xeroderma pigmentosum cells following split-dose ultraviolet irradiation. / Moustacchi, Ethel; Ehmann, Ursula K.; Friedberg, Errol C.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 62, No. 1, 08.1979, p. 159-171.

Research output: Contribution to journal › Article › peer-review

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abstract = "In normal human fibroblasts we observe an enhancement of the recovery of the rate of semi-conservative DNA synthesis after split-dose UV-irradiation relative to a single total UV dose. The enhanced recovery is totally absent in both a xeroderma pigmentosum variant line and two xeroderma pigmentosum lines belonging to complementation groups A and C.",

author = "Ethel Moustacchi and Ehmann, {Ursula K.} and Friedberg, {Errol C.}",

note = "Funding Information: These studies were supported by research grants from the U.S.P.H.S. (CA 12428) and A.C.S. (NP 174B) as well as by contract No. EY-76-S-03-0326 from the U.S. Department of Energy. E.M. was partly supported by a research fellowship from N.A.T.O.U.K.E. was supported by U.S.P.H.S. Training Grant GM 02236. E.C.F. acknowledges support by Research Career Development Award (5 K04 CA 71005) from the U.S.P.H.S.",

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