Defective thymine dimer excision by cell free extracts of xeroderma pigmentosum cells

K. Mortelmans, E. C. Friedberg, H. Slor, G. Thomas, J. E. Cleaver

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Abstract

Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell free preparations of cells that had been labeled with [ 3H]thymidine. Extracts of Xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell free preparations.

Original languageEnglish (US)
Pages (from-to)2757-2761
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume73
Issue number8
Publication statusPublished - 1976

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ASJC Scopus subject areas

  • Genetics
  • General

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