Defective thymine dimer excision by cell free extracts of xeroderma pigmentosum cells

K. Mortelmans; E. C. Friedberg; H. Slor; G. Thomas; J. E. Cleaver

doi:10.1073/pnas.73.8.2757

Defective thymine dimer excision by cell free extracts of xeroderma pigmentosum cells

K. Mortelmans, E. C. Friedberg, H. Slor, G. Thomas, J. E. Cleaver

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Abstract

Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell free preparations of cells that had been labeled with [³H]thymidine. Extracts of Xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell free preparations.

Original language	English (US)
Pages (from-to)	2757-2761
Number of pages	5
Journal	Unknown Journal
Volume	73
Issue number	8
DOIs	https://doi.org/10.1073/pnas.73.8.2757
State	Published - 1976

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abstract = "Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell free preparations of cells that had been labeled with [3H]thymidine. Extracts of Xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell free preparations.",

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AU - Friedberg, E. C.

AU - Slor, H.

AU - Thomas, G.

AU - Cleaver, J. E.

PY - 1976

Y1 - 1976

N2 - Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell free preparations of cells that had been labeled with [3H]thymidine. Extracts of Xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell free preparations.

AB - Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell free preparations of cells that had been labeled with [3H]thymidine. Extracts of Xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell free preparations.

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Defective thymine dimer excision by cell free extracts of xeroderma pigmentosum cells

Abstract

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