Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

Katsumi Iizuka, Richard K. Bruick, Guosheng Liang, Jay D. Horton, Kosaku Uyeda

Research output: Contribution to journalArticlepeer-review

481 Scopus citations

Abstract

The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

Original languageEnglish (US)
Pages (from-to)7281-7286
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number19
DOIs
StatePublished - May 11 2004

ASJC Scopus subject areas

  • General

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