Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

Research output: Contribution to journalArticle

435 Citations (Scopus)

Abstract

The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

Original languageEnglish (US)
Pages (from-to)7281-7286
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number19
DOIs
StatePublished - May 11 2004

Fingerprint

Lipogenesis
Response Elements
Glycolysis
Carrier Proteins
Carbohydrates
Liver
Fatty Acids
Fats
Insulin
Glucose
Carbohydrate Metabolism
Triglycerides
Transcription Factors
Enzymes

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

@article{54e58224f3c54131b11702c2c427b2c2,
title = "Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis",
abstract = "The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.",
author = "Katsumi Iizuka and Bruick, {Richard K.} and Guosheng Liang and Horton, {Jay D.} and Kosaku Uyeda",
year = "2004",
month = "5",
day = "11",
doi = "10.1073/pnas.0401516101",
language = "English (US)",
volume = "101",
pages = "7281--7286",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "19",

}

TY - JOUR

T1 - Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis

AU - Iizuka, Katsumi

AU - Bruick, Richard K.

AU - Liang, Guosheng

AU - Horton, Jay D.

AU - Uyeda, Kosaku

PY - 2004/5/11

Y1 - 2004/5/11

N2 - The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

AB - The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.

UR - http://www.scopus.com/inward/record.url?scp=2442435802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2442435802&partnerID=8YFLogxK

U2 - 10.1073/pnas.0401516101

DO - 10.1073/pnas.0401516101

M3 - Article

VL - 101

SP - 7281

EP - 7286

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 19

ER -