TY - JOUR
T1 - Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
AU - Iizuka, Katsumi
AU - Bruick, Richard K.
AU - Liang, Guosheng
AU - Horton, Jay D.
AU - Uyeda, Kosaku
PY - 2004/5/11
Y1 - 2004/5/11
N2 - The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.
AB - The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanisms that are independent of insulin. In this study, we show that the transcription factor, carbohydrate response element-binding protein (ChREBP), is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo.
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U2 - 10.1073/pnas.0401516101
DO - 10.1073/pnas.0401516101
M3 - Article
C2 - 15118080
AN - SCOPUS:2442435802
SN - 0027-8424
VL - 101
SP - 7281
EP - 7286
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 19
ER -