Abstract

The classic definition of hypercalciuria, an upper normal limit of 200 mg/day, is based on a constant diet restricted in calcium, sodium, and animal protein; however, random diet data challenge this. Here our retrospective study determined the validity of the classic definition of hypercalciuria by comparing data from 39 publications analyzing urinary calcium excretion on a constant restricted diet and testing whether hypercalciuria could be defined when extraneous dietary influences were controlled. These papers encompassed 300 non-stone-forming patients, 208 patients with absorptive hypercalciuria type I (presumed due to high intestinal calcium absorption), and 234 stone formers without absorptive hypercalciuria; all evaluated on a constant restricted diet. In non-stone formers, the mean urinary calcium was well below 200 mg/day, and the mean for all patients was 12746 mg/day with an upper limit of 219 mg/day. In absorptive hypercalciuria type I, the mean urinary calcium significantly exceeded 200 mg/day in all studies with a combined mean of 25955 mg/day. Receiver operating characteristic curve analysis showed the optimal cutoff point for urinary calcium excretion was 172 mg/day on a restricted diet, a value that approximates the traditional limit of 200 mg/day. Thus, on a restricted diet, a clear demarcation was seen between urinary calcium excretion of kidney stone formers with absorptive hypercalciuria type I and normal individuals. When dietary variables are controlled, the classic definition of hypercalciuria of nephrolithiasis appears valid.

Original languageEnglish (US)
Pages (from-to)777-782
Number of pages6
JournalKidney International
Volume80
Issue number7
DOIs
StatePublished - Oct 1 2011

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Hypercalciuria
Nephrolithiasis
Calcium
Diet
Kidney Calculi
Intestinal Absorption
ROC Curve
Publications
Retrospective Studies
Sodium

Keywords

  • absorptive hypercalciuria
  • hypercalciuria
  • nephrolithiasis

ASJC Scopus subject areas

  • Nephrology

Cite this

Defining hypercalciuria in nephrolithiasis. / Pak, Charles Y C; Sakhaee, Khashayar; Moe, Orson W.; Poindexter, John; Adams-Huet, Beverley.

In: Kidney International, Vol. 80, No. 7, 01.10.2011, p. 777-782.

Research output: Contribution to journalArticle

Pak, Charles Y C ; Sakhaee, Khashayar ; Moe, Orson W. ; Poindexter, John ; Adams-Huet, Beverley. / Defining hypercalciuria in nephrolithiasis. In: Kidney International. 2011 ; Vol. 80, No. 7. pp. 777-782.
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