Defining the signals that constitute the nephron progenitor niche

Thomas J. Carroll, Amrita Das

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


For decades we have known that reciprocal inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basis for kidney development. Signals from the mesenchyme promote the branching of the bud, whereas signals fromthe bud regulate the survival, proliferation, and differentiation of nephron progenitors. Due to the complex nature of the bud-derived signals, progress in identifying these factors has been slow. However, in the last several years, tremendous advances have beenmade in identifying specific roles for various secreted proteins in nephron progenitor cell development. Here, we briefly review the roles for Fgfs and Wnts in induction of the nephron progenitors.

Original languageEnglish (US)
Pages (from-to)873-876
Number of pages4
JournalJournal of the American Society of Nephrology
Issue number6
StatePublished - May 31 2013

ASJC Scopus subject areas

  • Nephrology


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