Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts

Dedee F. Murrell, Branka Marinovic, Frederic Caux, Catherine Prost, Razzaque Ahmed, Katarzyna Wozniak, Masayuki Amagai, Johann Bauer, Stefan Beissert, Luca Borradori, Donna Culton, Janet A. Fairley, David Fivenson, Marcel F. Jonkman, M. Peter Marinkovich, David Woodley, John Zone, Valeria Aoki, Philippe Bernard, Leen Bruckner-TudermanGiuseppe Cianchini, Vanessa Venning, Luis Diaz, Rudiger Eming, Sergei A. Grando, Russell P. Hall, Takashi Hashimoto, Josep E. Herrero-González, Michael Hertl, Pascal Joly, Sarolta Karpati, Jaehwan Kim, Soo Chan Kim, Neil J. Korman, Cezary Kowalewski, Sang Eun Lee, David R. Rubenstein, Eli Sprecher, Kim Yancey, Giovann Zambruno, Detlef Zillikens, Serge Doan, Benjamin S. Daniel, Victoria P. Werth

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.

Original languageEnglish (US)
Pages (from-to)168-174
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume72
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • consensus
  • definitions
  • mucous membrane pemphigoid
  • outcome measures
  • severity score

ASJC Scopus subject areas

  • Dermatology

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    Murrell, D. F., Marinovic, B., Caux, F., Prost, C., Ahmed, R., Wozniak, K., Amagai, M., Bauer, J., Beissert, S., Borradori, L., Culton, D., Fairley, J. A., Fivenson, D., Jonkman, M. F., Marinkovich, M. P., Woodley, D., Zone, J., Aoki, V., Bernard, P., ... Werth, V. P. (2015). Definitions and outcome measures for mucous membrane pemphigoid: Recommendations of an international panel of experts. Journal of the American Academy of Dermatology, 72(1), 168-174. https://doi.org/10.1016/j.jaad.2014.08.024