Definitions of pediatric pancreatitis and survey of present clinical practices

Veronique D. Morinville, Sohail Z. Husain, Harrison Bai, Bradley Barth, Rabea Alhosh, Peter R. Durie, Steven D. Freedman, Ryan Himes, Mark E. Lowe, John Pohl, Steven Werlin, Michael Wilschanski, Aliye Uc

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Objectives: There is limited literature on acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) in children. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was formed to standardize definitions, develop diagnostic algorithms, investigate disease pathophysiology, and design prospective multicenter studies in pediatric pancreatitis. Methods: Subcommittees were formed to delineate definitions of pancreatitis, and a survey was conducted to analyze present practice. Results: AP was defined as requiring 2 of the following: abdominal pain compatible with AP, serum amylase and/or lipase values 3 times upper limits of normal, and imaging findings of AP. ARP was defined as 2 distinct episodes of AP with intervening return to baseline. CP was diagnosed in the presence of typical abdominal pain plus characteristic imaging findings, or exocrine insufficiency plus imaging findings, or endocrine insufficiency plus imaging findings. We found that children with pancreatitis were primarily managed by pediatric gastroenterologists. Unless the etiology was known, initial investigations included serum liver enzymes, triglycerides, calcium, and abdominal ultrasound. Further investigations (usually for ARP and CP) included magnetic resonance or other imaging, sweat chloride, and genetic testing. Respondents' future goals for INSPPIRE included determining natural history of pancreatitis, developing algorithms to evaluate and manage pancreatitis, and validating diagnostic criteria. Conclusions: INSPPIRE represents the first initiative to create a multicenter approach to systematically characterize pancreatitis in children. Future aims include creation of patient database and biologic sample repository.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume55
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Pancreatitis
Pediatrics
Chronic Pancreatitis
Surveys and Questionnaires
Abdominal Pain
Sweat
Genetic Testing
Amylases
Serum
Lipase
Multicenter Studies
Chlorides
Triglycerides
Magnetic Resonance Spectroscopy

Keywords

  • acute pancreatitis
  • acute recurrent pancreatitis
  • chronic pancreatitis
  • definitions
  • pediatrics
  • practice parameters

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Definitions of pediatric pancreatitis and survey of present clinical practices. / Morinville, Veronique D.; Husain, Sohail Z.; Bai, Harrison; Barth, Bradley; Alhosh, Rabea; Durie, Peter R.; Freedman, Steven D.; Himes, Ryan; Lowe, Mark E.; Pohl, John; Werlin, Steven; Wilschanski, Michael; Uc, Aliye.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 55, No. 3, 09.2012, p. 261-265.

Research output: Contribution to journalArticle

Morinville, VD, Husain, SZ, Bai, H, Barth, B, Alhosh, R, Durie, PR, Freedman, SD, Himes, R, Lowe, ME, Pohl, J, Werlin, S, Wilschanski, M & Uc, A 2012, 'Definitions of pediatric pancreatitis and survey of present clinical practices', Journal of Pediatric Gastroenterology and Nutrition, vol. 55, no. 3, pp. 261-265. https://doi.org/10.1097/MPG.0b013e31824f1516
Morinville, Veronique D. ; Husain, Sohail Z. ; Bai, Harrison ; Barth, Bradley ; Alhosh, Rabea ; Durie, Peter R. ; Freedman, Steven D. ; Himes, Ryan ; Lowe, Mark E. ; Pohl, John ; Werlin, Steven ; Wilschanski, Michael ; Uc, Aliye. / Definitions of pediatric pancreatitis and survey of present clinical practices. In: Journal of Pediatric Gastroenterology and Nutrition. 2012 ; Vol. 55, No. 3. pp. 261-265.
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