Dehydrogenative coupling to enable the enantioselective total synthesis of (-)-simaomicin α

Yizhong Wang, Chao Wang, John R. Butler, Joseph M. Ready

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The anticancer natural product simaomicin α has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram-positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethyl.

Original languageEnglish (US)
Pages (from-to)10796-10799
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number41
DOIs
StatePublished - Oct 4 2013

Keywords

  • cytotoxicity
  • dehydrogenative coupling
  • natural products
  • simaomicin
  • xanthone

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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