Delayed‐Type Hypersensitivity to Ovalbumin in Bone Marrow Chimeric Mice

M. T. Lubet, J. R. Kettman

Research output: Contribution to journalArticle

Abstract

The site of action of the H‐2 linked gene regulating the ability of mice to be sensitized to transfer delayed‐type hypersensitivity was studied using radiation bone marrow chimeras. Lethally irradiated (non‐responder × responder) F1 were reconstituted with bone marrow cells of both parents. Cells of chimeras immunized with limiting doses of ovalbumin responded as did the parental strains. These results suggest that the gene regulating delayed type hypersensitivity is expressed at the level of the delayed‐type hypersensitivity effector cells or that restrictions exits on the collaboration of the helper cells for DTH effectors (which differ at several loci including the major histocompatibility complex).

Original languageEnglish (US)
Pages (from-to)263-267
Number of pages5
JournalScandinavian Journal of Immunology
Volume14
Issue number3
DOIs
StatePublished - Sep 1981

ASJC Scopus subject areas

  • Immunology

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