Deletion of the NF2 region in both meningioma and juxtaposed meningioangiomatosis: Case report supporting a neoplastic relationship

Prasanna Sinkre, Arie Perry, Dan Cai, Ravi Raghavan, Mark Watson, Kathleen Wilson, Beverly Barton Rogers

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

We report a case of juxtaposed atypical meningioma and meningioangiomatosis (MA) in an 8-year-old boy with no clinical stigmata or family history of neurofibromatoms. We studied the proliferative activity and genetic changes in the two lesions in an attempt to define their biologic and pathogenetic relationships. The MIB-1 index was 11% in the meningioma and <1% in the MA, indicating increased proliferative activity in the meningioma. Fluorescence in situ hybridization was done for two chromosomal regions commonly deleted in meningiomas. There was loss of the neurofibromatosis 2 locus (22q12) in both the meningioma and MA. Conversely, the region of 1p32 was not deleted. Our results indicate that both the meningioma and MA arose front the same clonal process, with the meningioma probably undergoing additional, but undefined, genetic alterations that confer upon it a more proliferative potential. This loss of 22q12 in the MA raises doubt about the presumed hamartomatous nature of MA.

Original languageEnglish (US)
Pages (from-to)568-572
Number of pages5
JournalPediatric and Developmental Pathology
Volume4
Issue number6
DOIs
StatePublished - Nov 22 2001

Keywords

  • Chromosome 22
  • Fluorescence in situ hybridization
  • Meningioangiomatosis
  • Meningioma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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