Delineating the genetic basis of systemic lupus erythematosus

Edward K. Wakeland, Kui Liu, Robert R. Graham, Timothy W. Behrens

Research output: Contribution to journalReview articlepeer-review

469 Scopus citations

Abstract

Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which genetic interactions mediate severe disease pathogenesis. Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development.

Original languageEnglish (US)
Pages (from-to)397-408
Number of pages12
JournalImmunity
Volume15
Issue number3
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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