Delivery of the porcupine inhibitor WNT974 in mice

Li Shu Zhang, Lawrence Lum

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

We describe here a technique for delivering the porcupine inhibitor WNT974 (formerly LGK974) in mice. The protocol entails once-a-day oral delivery of WNT974 for up to 3 months at a concentration sufficient to achieve systemic Wnt pathway inhibition with limited toxicity as measured by weight change. This route of delivery enables extended durations of Wnt signaling inhibition in a mammalian model organism.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages111-117
Number of pages7
DOIs
StatePublished - 2016

Publication series

NameMethods in Molecular Biology
Volume1481
ISSN (Print)1064-3745

Keywords

  • Drug delivery
  • Mice
  • Porcupine
  • Wnt974/LGK974

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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