Abstract
Purpose: In order to improve the immunogenicity of whole tumor cell lysate for tumor vaccine, we have designed a series of CpG ODNs to study their transport and to evaluate their anti-tumor activity in B16 melanoma mouse models. Methods: In this study, we investigated whether C-class CpG ODN (CpG ODN-685) could facilitate tumor cell lysate to induce vigorous anti-tumor activity against tumors in mice both prophylactically and therapeutically. Results: It was found that the combination of tumor cell lysate and CpG ODN-685 could inhibit the growth of B16 melanoma and prolong the survival of tumor-bearing mice. Moreover CpG ODN-685 with the addition of tumor cell lysate can also cause the generation of tumor specific immune memory by inducing specific cytotoxic T lymphocytes and helper T lymphocytes in mice. Conclusion: The results suggest that CpG ODN-685 could be developed as an efficient adjuvant for tumor vaccines against melanoma.
Original language | English (US) |
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Pages (from-to) | 241-250 |
Number of pages | 10 |
Journal | Journal of Cancer |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - 2016 |
Externally published | Yes |
Keywords
- CpG ODN
- Melanoma
- T lymphocytes
- Tumor cell lysate
ASJC Scopus subject areas
- Oncology