Delivery system of CpG oligodeoxynucleotides through eliciting an effective T cell immune response against melanoma in mice

Wei Sun, Mingli Fang, Yajing Chen, Zhaogang Yang, Yue Xiao, Min Wan, Hua Wang, Yongli Yu, Liying Wang

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Purpose: In order to improve the immunogenicity of whole tumor cell lysate for tumor vaccine, we have designed a series of CpG ODNs to study their transport and to evaluate their anti-tumor activity in B16 melanoma mouse models. Methods: In this study, we investigated whether C-class CpG ODN (CpG ODN-685) could facilitate tumor cell lysate to induce vigorous anti-tumor activity against tumors in mice both prophylactically and therapeutically. Results: It was found that the combination of tumor cell lysate and CpG ODN-685 could inhibit the growth of B16 melanoma and prolong the survival of tumor-bearing mice. Moreover CpG ODN-685 with the addition of tumor cell lysate can also cause the generation of tumor specific immune memory by inducing specific cytotoxic T lymphocytes and helper T lymphocytes in mice. Conclusion: The results suggest that CpG ODN-685 could be developed as an efficient adjuvant for tumor vaccines against melanoma.

Original languageEnglish (US)
Pages (from-to)241-250
Number of pages10
JournalJournal of Cancer
Volume7
Issue number3
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • CpG ODN
  • Melanoma
  • T lymphocytes
  • Tumor cell lysate

ASJC Scopus subject areas

  • Oncology

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