Abstract
Ye et al. demonstrate that demethylation of PP2A in response to methionine starvation activates histone demethylation by increasing phosphorylation and chromatin binding of demethylase enzymes, which prepares the histones for remethylation that fuels cysteine synthesis. This regulatory mechanism also enables cells to preserve SAM by increasing SAH to limit SAM consumption by methyltransferases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1115-1126.e6 |
| Journal | Molecular cell |
| Volume | 73 |
| Issue number | 6 |
| DOIs | |
| State | Published - Mar 21 2019 |
Fingerprint
Keywords
- chromatin
- demethylation
- epigenetics
- histones
- metabolism
- methylation
- SAM
- signaling
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink. / Ye, Cunqi; Sutter, Benjamin M.; Wang, Yun; Kuang, Zheng; Zhao, Xiaozheng; Yu, Yonghao; Tu, Benjamin P.
In: Molecular cell, Vol. 73, No. 6, 21.03.2019, p. 1115-1126.e6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink
AU - Ye, Cunqi
AU - Sutter, Benjamin M.
AU - Wang, Yun
AU - Kuang, Zheng
AU - Zhao, Xiaozheng
AU - Yu, Yonghao
AU - Tu, Benjamin P
PY - 2019/3/21
Y1 - 2019/3/21
N2 - Ye et al. demonstrate that demethylation of PP2A in response to methionine starvation activates histone demethylation by increasing phosphorylation and chromatin binding of demethylase enzymes, which prepares the histones for remethylation that fuels cysteine synthesis. This regulatory mechanism also enables cells to preserve SAM by increasing SAH to limit SAM consumption by methyltransferases.
AB - Ye et al. demonstrate that demethylation of PP2A in response to methionine starvation activates histone demethylation by increasing phosphorylation and chromatin binding of demethylase enzymes, which prepares the histones for remethylation that fuels cysteine synthesis. This regulatory mechanism also enables cells to preserve SAM by increasing SAH to limit SAM consumption by methyltransferases.
KW - chromatin
KW - demethylation
KW - epigenetics
KW - histones
KW - metabolism
KW - methylation
KW - SAM
KW - signaling
UR - http://www.scopus.com/inward/record.url?scp=85063066625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063066625&partnerID=8YFLogxK
U2 - 10.1016/j.molcel.2019.01.012
DO - 10.1016/j.molcel.2019.01.012
M3 - Article
C2 - 30772176
AN - SCOPUS:85063066625
VL - 73
SP - 1115-1126.e6
JO - Molecular Cell
JF - Molecular Cell
SN - 1097-2765
IS - 6
ER -