Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink

Cunqi Ye, Benjamin M. Sutter, Yun Wang, Zheng Kuang, Xiaozheng Zhao, Yonghao Yu, Benjamin P Tu

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Ye et al. demonstrate that demethylation of PP2A in response to methionine starvation activates histone demethylation by increasing phosphorylation and chromatin binding of demethylase enzymes, which prepares the histones for remethylation that fuels cysteine synthesis. This regulatory mechanism also enables cells to preserve SAM by increasing SAH to limit SAM consumption by methyltransferases.

Original languageEnglish (US)
Pages (from-to)1115-1126.e6
JournalMolecular cell
Volume73
Issue number6
DOIs
StatePublished - Mar 21 2019

Keywords

  • chromatin
  • demethylation
  • epigenetics
  • histones
  • metabolism
  • methylation
  • SAM
  • signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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