@article{a717947deec14f6fa35c55f674ca7e77,
title = "Demethylation of the Protein Phosphatase PP2A Promotes Demethylation of Histones to Enable Their Function as a Methyl Group Sink",
abstract = "Ye et al. demonstrate that demethylation of PP2A in response to methionine starvation activates histone demethylation by increasing phosphorylation and chromatin binding of demethylase enzymes, which prepares the histones for remethylation that fuels cysteine synthesis. This regulatory mechanism also enables cells to preserve SAM by increasing SAH to limit SAM consumption by methyltransferases.",
keywords = "SAM, chromatin, demethylation, epigenetics, histones, metabolism, methylation, signaling",
author = "Cunqi Ye and Sutter, {Benjamin M.} and Yun Wang and Zheng Kuang and Xiaozheng Zhao and Yonghao Yu and Tu, {Benjamin P.}",
note = "Funding Information: The authors acknowledge funding support from the Chilton Foundation and NIH grant K99GM129415 to C.Y., NIH R01GM114160 and R01GM122932 and Welch Foundation (I-1800) to Y.Y., and NIH grant R01GM094314, the Welch Foundation (I-1797), and a HHMI-Simons Faculty Scholar Award to B.P.T. Funding Information: The authors acknowledge funding support from the Chilton Foundation and NIH grant K99GM129415 to C.Y., NIH R01GM114160 and R01GM122932 and Welch Foundation ( I-1800 ) to Y.Y., and NIH grant R01GM094314 , the Welch Foundation ( I-1797 ), and a HHMI-Simons Faculty Scholar Award to B.P.T. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = mar,
day = "21",
doi = "10.1016/j.molcel.2019.01.012",
language = "English (US)",
volume = "73",
pages = "1115--1126.e6",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",
}